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    Tysnd1 trypsin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71767, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tysnd1provided by MGI
    Official Full Name
    trypsin domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919017
    See related
    Ensembl:ENSMUSG00000020087 AllianceGenome:MGI:1919017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300019N10Rik
    Summary
    This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Broad expression in adrenal adult (RPKM 220.9), duodenum adult (RPKM 66.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tysnd1 in Genome Data Viewer
    Location:
    10 B4; 10 32.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61531279..61538552)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61695500..61702773)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700022H01 gene Neighboring gene STARR-positive B cell enhancer ABC_E9032 Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene STARR-positive B cell enhancer ABC_E1800 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 2 Neighboring gene STARR-seq mESC enhancer starr_26853 Neighboring gene macroH2A.2 histone Neighboring gene STARR-seq mESC enhancer starr_26854 Neighboring gene microRNA 5108

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence-based discovery of the human and rodent peroxisomal proteome. Kurochkin IV, et al. Appl Bioinformatics, 2005. PMID 16128611
    2. Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. Mizuno Y, et al. PLoS Genet, 2013. PMID 23459139, Free PMC Article
    3. Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids. Kurochkin IV, et al. EMBO J, 2007 Feb 7. PMID 17255948, Free PMC Article
    4. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix. Okumoto K, et al. J Biol Chem, 2011 Dec 30. PMID 22002062, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data established that peroxisomal processing protease Tysnd1 is necessary to mediate the physiological functions of PTS2-containing substrates.
      Title: Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility.
    2. characterization of function of human TYSND1, including putative regulation by self-cleavage
      Title: Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal leader peptide-processing protease
    Names
    trypsin domain-containing protein 1
    NP_001259019.1
    NP_001259020.1
    NP_001259021.1
    NP_082188.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272090.1 → NP_001259019.1  peroxisomal leader peptide-processing protease isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC153136, AI181257, AK005069
      UniProtKB/Swiss-Prot
      Q9DBA6
      Conserved Domains (2) summary
      pfam13365
      Location:359 → 429
      Trypsin_2; Trypsin-like peptidase domain
      cl21584
      Location:187 → 268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001272091.1 → NP_001259020.1  peroxisomal leader peptide-processing protease isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC153136, AK005069
      UniProtKB/Swiss-Prot
      Q9DBA6
      Conserved Domains (1) summary
      cl21584
      Location:187 → 268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_001272092.1 → NP_001259021.1  peroxisomal leader peptide-processing protease isoform d

      See identical proteins and their annotated locations for NP_001259021.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC153136, AK005069
      UniProtKB/Swiss-Prot
      Q9DBA6
      Conserved Domains (2) summary
      pfam13365
      Location:359 → 460
      Trypsin_2; Trypsin-like peptidase domain
      cl21584
      Location:187 → 268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. NM_027912.1 → NP_082188.1  peroxisomal leader peptide-processing protease isoform a

      See identical proteins and their annotated locations for NP_082188.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC153136, AK005069, AV148467
      Consensus CDS
      CCDS48575.1
      UniProtKB/Swiss-Prot
      Q0VE90, Q9DBA6
      Related
      ENSMUSP00000020284.5, ENSMUST00000020284.5
      Conserved Domains (3) summary
      pfam00089
      Location:344 → 528
      Trypsin; Trypsin
      pfam13365
      Location:359 → 498
      Trypsin_2; Trypsin-like peptidase domain
      cl21584
      Location:187 → 268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_073587.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC153136, AK005069, BE847683

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61531279..61538552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003948807.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBA6.1 GenPept UniProtKB/Swiss-Prot:Q9DBA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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