Cep192 centrosomal protein 192 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep192provided by MGI
Official Full Name: centrosomal protein 192provided by MGI
Primary source: MGI:MGI:1918049
See related: Ensembl:ENSMUSG00000024542 AllianceGenome:MGI:1918049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4631422C13Rik; D430014P18Rik
Summary: Predicted to enable phosphatase binding activity and protein kinase binding activity. Acts upstream of or within response to bacterium. Located in cytoplasm and pericentriolar material. Orthologous to human CEP192 (centrosomal protein 192). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.7), limb E14.5 (RPKM 5.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1- E2; 18 40.11 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (67933124..68018241)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (67800054..67885170)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
Title: Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
results demonstrate the different roles of Cep192 and Cep152 in MTOC remodeling and a novel regulatory mechanism during meiotic spindle formation in mouse oocytes.
Title: Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation.
CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation in mouse oocytes
Title: CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237835

SHGC-152266 (e-PCR)
- UniSTS:177452

AW540070 (e-PCR)
- UniSTS:181142

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in centriole replication	NAS Non-traceable Author Statement more info	PubMed
involved_in centrosome-templated microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome-templated microtubule nucleation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule nucleation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of centriole replication	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of centrosome cycle	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of establishment of protein localization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in pericentriolar material	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
located_in procentriole	ISO Inferred from Sequence Orthology more info
part_of procentriole replication complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 192 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027556.1 → NP_081832.1 centrosomal protein of 192 kDa

Status: VALIDATED

Source sequence(s)

AC127236, AK052420, AK158414, BC064462, BE982606, CD538408, CK391255, CK639048, CO045915

Consensus CDS

CCDS50313.1

UniProtKB/TrEMBL

E9Q4Y4

Related

ENSMUSP00000025425.6, ENSMUST00000025425.7

Conserved Domains (1) summary

cl13764
Location:1636 → 1703

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

67933124..68018241

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526241.3 → XP_006526304.1 centrosomal protein of 192 kDa isoform X1

See identical proteins and their annotated locations for XP_006526304.1

Conserved Domains (2) summary

pfam08626
Location:1651 → 1772

TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

cl13764
Location:1636 → 1703

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_011247001.4 → XP_011245303.1 centrosomal protein of 192 kDa isoform X5

Conserved Domains (2) summary

pfam08626
Location:1651 → 1772

TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

cl13764
Location:1636 → 1703

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_006526243.4 → XP_006526306.1 centrosomal protein of 192 kDa isoform X2

Conserved Domains (2) summary

pfam08626
Location:1608 → 1729

TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

cl13764
Location:1593 → 1660

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_006526242.3 → XP_006526305.1 centrosomal protein of 192 kDa isoform X1

See identical proteins and their annotated locations for XP_006526305.1

Conserved Domains (2) summary

pfam08626
Location:1651 → 1772

TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

cl13764
Location:1636 → 1703

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_036161275.1 → XP_036017168.1 centrosomal protein of 192 kDa isoform X3

Conserved Domains (1) summary

cl13764
Location:1406 → 1473

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_011247000.4 → XP_011245302.1 centrosomal protein of 192 kDa isoform X4

Conserved Domains (2) summary

pfam08626
Location:1019 → 1140

TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

cl13764
Location:1004 → 1071

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin