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    Trappc8 trafficking protein particle complex 8 [ Mus musculus (house mouse) ]

    Gene ID: 75964, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trappc8provided by MGI
    Official Full Name
    trafficking protein particle complex 8provided by MGI
    Primary source
    MGI:MGI:2443008
    See related
    Ensembl:ENSMUSG00000033382 AllianceGenome:MGI:2443008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trs85; mKIAA1012; 5033403J15Rik; D030074E01Rik
    Summary
    Predicted to be involved in several processes, including autophagy of peroxisome; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein localization to phagophore assembly site. Predicted to be part of TRAPPIII protein complex. Predicted to be active in cytoplasmic vesicle and phagophore assembly site. Orthologous to human TRAPPC8 (trafficking protein particle complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.0), CNS E18 (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 A2; 18 11.53 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20950268..21033851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20817211..20896425, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35 pseudogene Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 Neighboring gene predicted gene, 31437 Neighboring gene STARR-seq mESC enhancer starr_43979 Neighboring gene STARR-seq mESC enhancer starr_43980 Neighboring gene STARR-seq mESC enhancer starr_43983 Neighboring gene STARR-seq mESC enhancer starr_43987 Neighboring gene STARR-seq mESC enhancer starr_43988 Neighboring gene STARR-positive B cell enhancer ABC_E11655 Neighboring gene STARR-seq mESC enhancer starr_43995 Neighboring gene STARR-seq mESC enhancer starr_43996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:21115655-21115838 Neighboring gene ring finger protein 125 Neighboring gene STARR-seq mESC enhancer starr_43997 Neighboring gene STARR-positive B cell enhancer ABC_E3224 Neighboring gene STARR-seq mESC enhancer starr_43999 Neighboring gene ring finger protein 138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Wang J, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716696, Free PMC Article
    2. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
    3. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPPIII protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPIII protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361188.1 → NP_001348117.1  trafficking protein particle complex subunit 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC122118, AC129078
      Conserved Domains (1) summary
      pfam12739
      Location:157 → 589
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    2. NM_001379370.1 → NP_001366299.1  trafficking protein particle complex subunit 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122118, AC129078
      Conserved Domains (1) summary
      pfam12739
      Location:160 → 603
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    3. NM_029491.2 → NP_083767.2  trafficking protein particle complex subunit 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK083747, AW912577
      Consensus CDS
      CCDS29087.1
      UniProtKB/TrEMBL
      E9PY51, Q8BJI6
      Related
      ENSMUSP00000095262.2, ENSMUST00000097658.2
      Conserved Domains (1) summary
      pfam12739
      Location:158 → 604
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    4. NM_177038.3 → NP_796012.2  trafficking protein particle complex subunit 8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK083747, AK173085, AW552459
      Consensus CDS
      CCDS50233.1
      UniProtKB/TrEMBL
      A0A286YCX6
      Related
      ENSMUSP00000153183.3, ENSMUST00000225661.3
      Conserved Domains (1) summary
      pfam12739
      Location:158 → 604
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      20950268..21033851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250631.2 → XP_030106491.1  trafficking protein particle complex subunit 8 isoform X12

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 570
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    2. XM_011247033.4 → XP_011245335.1  trafficking protein particle complex subunit 8 isoform X11

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 577
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    3. XM_030250630.2 → XP_030106490.1  trafficking protein particle complex subunit 8 isoform X10

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 585
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    4. XM_011247032.4 → XP_011245334.1  trafficking protein particle complex subunit 8 isoform X8

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 592
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    5. XM_030250629.2 → XP_030106489.1  trafficking protein particle complex subunit 8 isoform X9

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 589
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    6. XM_011247031.4 → XP_011245333.1  trafficking protein particle complex subunit 8 isoform X7

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 596
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    7. XM_030250628.2 → XP_030106488.1  trafficking protein particle complex subunit 8 isoform X5

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 603
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    8. XM_011247028.4 → XP_011245330.1  trafficking protein particle complex subunit 8 isoform X2

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 610
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    9. XM_011247029.4 → XP_011245331.1  trafficking protein particle complex subunit 8 isoform X4

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 604
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    10. XM_017318012.3 → XP_017173501.1  trafficking protein particle complex subunit 8 isoform X3

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 610
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    11. XM_011247030.4 → XP_011245332.1  trafficking protein particle complex subunit 8 isoform X6

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 611
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    12. XM_017318011.3 → XP_017173500.1  trafficking protein particle complex subunit 8 isoform X1

      Conserved Domains (1) summary
      pfam12739
      Location:157 → 611
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    RNA

    1. XR_001782396.3 RNA Sequence

    2. XR_001782397.3 RNA Sequence

    3. XR_004939888.1 RNA Sequence

    4. XR_001782399.3 RNA Sequence

    5. XR_001782398.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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