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    Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 382051, updated on 20-Apr-2024

    Summary

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    Official Symbol
    Pdp2provided by MGI
    Official Full Name
    pyruvate dehydrogenase phosphatase catalytic subunit 2provided by MGI
    Primary source
    MGI:MGI:1918878
    See related
    Ensembl:ENSMUSG00000048371 AllianceGenome:MGI:1918878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PDP 2; Gm1705; PDPC 2; mKIAA1348; 4833426J09Rik
    Summary
    Predicted to enable [pyruvate dehydrogenase (lipoamide)] phosphatase activity and protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and positive regulation of pyruvate dehydrogenase activity. Located in mitochondrion. Is expressed in cerebral cortex. Orthologous to human PDP2 (pyruvate dehyrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 11.2), heart adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 53.04 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105318104..105325658)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104591472..104599026)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6676 Neighboring gene carbonic anhydrase 7 Neighboring gene STARR-positive B cell enhancer ABC_E2873 Neighboring gene STARR-seq mESC enhancer starr_22513 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1767 Neighboring gene STARR-seq mESC enhancer starr_22514 Neighboring gene STARR-positive B cell enhancer mm9_chr8:107126666-107126966 Neighboring gene VISTA enhancer mm1666 Neighboring gene cadherin 16 Neighboring gene Ras-related associated with diabetes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation. Kono M, et al. Proc Natl Acad Sci U S A, 2018 Sep 11. PMID 30150402, Free PMC Article
    2. BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Yu C, et al. Nat Struct Mol Biol, 2016 May. PMID 27065194
    3. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article
    4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1348

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T-helper cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial
    Names
    pyruvate dehydrogenase phosphatase isoenzyme 2
    pyruvate dehyrogenase phosphatase catalytic subunit 2
    NP_001019777.1
    XP_006531223.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024606.2 → NP_001019777.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

      See identical proteins and their annotated locations for NP_001019777.1

      Status: VALIDATED

      Source sequence(s)
      AC138617
      Consensus CDS
      CCDS22582.1
      UniProtKB/Swiss-Prot
      Q504M2
      UniProtKB/TrEMBL
      Q5DTY5
      Related
      ENSMUSP00000092821.4, ENSMUST00000059588.8
      Conserved Domains (1) summary
      cd00143
      Location:112 → 520
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105318104..105325658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531160.4 → XP_006531223.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006531223.1

      UniProtKB/Swiss-Prot
      Q504M2
      UniProtKB/TrEMBL
      Q5DTY5
      Conserved Domains (1) summary
      cd00143
      Location:112 → 520
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q504M2.1 GenPept UniProtKB/Swiss-Prot:Q504M2

    Gene LinkOut

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