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    Cep72 centrosomal protein 72 [ Mus musculus (house mouse) ]

    Gene ID: 74470, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cep72provided by MGI
    Official Full Name
    centrosomal protein 72provided by MGI
    Primary source
    MGI:MGI:1921720
    See related
    Ensembl:ENSMUSG00000021572 AllianceGenome:MGI:1921720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610029E11Rik; 4933440J22Rik
    Summary
    Enables identical protein binding activity. Predicted to be involved in gamma-tubulin complex localization; microtubule cytoskeleton organization; and regulation of protein localization to centrosome. Located in centriolar satellite. Orthologous to human CEP72 (centrosomal protein 72). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 18.9), CNS E11.5 (RPKM 3.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep72 in Genome Data Viewer
    Location:
    13 C1; 13 40.15 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74184351..74210439, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74036495..74062319, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15912 Neighboring gene tubulin polymerization promoting protein Neighboring gene integrin linked kinase pseudogene Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 Neighboring gene predicted gene, 41003 Neighboring gene exocyst complex component 3 Neighboring gene STARR-positive B cell enhancer ABC_E8534

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Cep72 affects the morphology of spermatozoa in mice. Chen Z, et al. Front Physiol, 2022. PMID 36277211, Free PMC Article
    2. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Stowe TR, et al. Mol Biol Cell, 2012 Sep. PMID 22767577, Free PMC Article
    3. Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. Hall EA, et al. PLoS Genet, 2013. PMID 24415959, Free PMC Article
    4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamma-tubulin complex localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 72 kDa
    Names
    centrosomal protein 72 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028959.3 → NP_083235.3  centrosomal protein of 72 kDa

      See identical proteins and their annotated locations for NP_083235.3

      Status: VALIDATED

      Source sequence(s)
      AK034892, CJ079657
      Consensus CDS
      CCDS26639.1
      UniProtKB/Swiss-Prot
      E9QQ95, Q3TU12, Q497H8, Q69ZH7, Q8BM53, Q9D0B7, Q9D3R3
      Related
      ENSMUSP00000037788.7, ENSMUST00000036456.8
      Conserved Domains (4) summary
      smart00446
      Location:117 → 134
      LRRcap; occurring C-terminal to leucine-rich repeats
      sd00031
      Location:55 → 76
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:53 → 93
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:28 → 85
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74184351..74210439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517423.5 → XP_006517486.1  centrosomal protein of 72 kDa isoform X4

      UniProtKB/TrEMBL
      A0A1Y7VJU1
      Related
      ENSMUSP00000152641.2, ENSMUST00000222609.2
      Conserved Domains (3) summary
      TIGR04211
      Location:395 → 541
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:55 → 76
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51 → 150
      LRR_9; Leucine-rich repeat

    2. XM_006517422.5 → XP_006517485.1  centrosomal protein of 72 kDa isoform X3

      Conserved Domains (3) summary
      TIGR04211
      Location:416 → 562
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:55 → 76
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51 → 150
      LRR_9; Leucine-rich repeat

    3. XM_011244576.4 → XP_011242878.1  centrosomal protein of 72 kDa isoform X1

      Conserved Domains (3) summary
      TIGR04211
      Location:475 → 621
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:55 → 76
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51 → 150
      LRR_9; Leucine-rich repeat

    4. XM_030247437.2 → XP_030103297.1  centrosomal protein of 72 kDa isoform X2

      Conserved Domains (4) summary
      TIGR04211
      Location:426 → 572
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:6 → 27
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:55 → 80
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam14580
      Location:2 → 101
      LRR_9; Leucine-rich repeat

    5. XM_030247438.2 → XP_030103298.1  centrosomal protein of 72 kDa isoform X7

      Conserved Domains (3) summary
      TIGR04211
      Location:395 → 541
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:55 → 76
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51 → 150
      LRR_9; Leucine-rich repeat

    6. XM_006517424.5 → XP_006517487.1  centrosomal protein of 72 kDa isoform X5

      UniProtKB/TrEMBL
      A0A1Y7VJU1
      Conserved Domains (3) summary
      sd00031
      Location:55 → 76
      LRR_1; leucine-rich repeat [structural motif]
      pfam10498
      Location:446 → 557
      IFT57; Intra-flagellar transport protein 57
      pfam14580
      Location:51 → 150
      LRR_9; Leucine-rich repeat

    7. XM_006517425.5 → XP_006517488.1  centrosomal protein of 72 kDa isoform X6

      UniProtKB/TrEMBL
      A0A1Y7VJU1
      Conserved Domains (3) summary
      sd00031
      Location:55 → 76
      LRR_1; leucine-rich repeat [structural motif]
      pfam10498
      Location:446 → 555
      IFT57; Intra-flagellar transport protein 57
      pfam14580
      Location:51 → 150
      LRR_9; Leucine-rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3R3.3 GenPept UniProtKB/Swiss-Prot:Q9D3R3

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