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    Rnf125 ring finger protein 125 [ Mus musculus (house mouse) ]

    Gene ID: 67664, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnf125provided by MGI
    Official Full Name
    ring finger protein 125provided by MGI
    Primary source
    MGI:MGI:1914914
    See related
    Ensembl:ENSMUSG00000033107 AllianceGenome:MGI:1914914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930553F04Rik; C730049O14Rik
    Summary
    Enables ubiquitin-protein transferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in Golgi membrane. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human RNF125 (ring finger protein 125). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 19.3), testis adult (RPKM 9.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18; 18 A2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (21077672..21120416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20944615..20987359)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 Neighboring gene STARR-seq mESC enhancer starr_43979 Neighboring gene predicted gene, 31437 Neighboring gene STARR-seq mESC enhancer starr_43980 Neighboring gene STARR-seq mESC enhancer starr_43983 Neighboring gene STARR-seq mESC enhancer starr_43987 Neighboring gene STARR-seq mESC enhancer starr_43988 Neighboring gene trafficking protein particle complex 8 Neighboring gene STARR-positive B cell enhancer ABC_E11655 Neighboring gene STARR-seq mESC enhancer starr_43995 Neighboring gene STARR-seq mESC enhancer starr_43996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:21115655-21115838 Neighboring gene STARR-seq mESC enhancer starr_43997 Neighboring gene STARR-positive B cell enhancer ABC_E3224 Neighboring gene STARR-seq mESC enhancer starr_43999 Neighboring gene ring finger protein 138 Neighboring gene STARR-seq mESC enhancer starr_44001 Neighboring gene STARR-seq mESC enhancer starr_44006 Neighboring gene ribosomal protein L27A pseudogene Neighboring gene meprin 1 beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression. Jiang C, et al. Mol Biotechnol, 2023 Jun. PMID 36344734
    2. The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation. Jia X, et al. J Immunol, 2017 Jun 15. PMID 28476934
    3. MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125. Zhu B, et al. J Immunol, 2015 Sep 1. PMID 26202983
    4. Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Arimoto K, et al. Proc Natl Acad Sci U S A, 2007 May 1. PMID 17460044, Free PMC Article
    5. Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia. Tang J, et al. J Exp Med, 2020 Apr 6. PMID 31999304, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.
      Title: CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.
    2. E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression.
      Title: E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression.
    3. Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.
      Title: Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.
    4. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response
      Title: The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.
    5. Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a reciprocal correlation between microRNA miR-15b levels and the expression of ring finger protein 125 (RNF125).
      Title: MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.
    6. RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production
      Title: Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of VCP-NPL4-UFD1 AAA ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF125
    NP_001351902.1
    NP_080577.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364973.1 → NP_001351902.1  E3 ubiquitin-protein ligase RNF125 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138611, AK016103, AK050462, BF148133, BY099954
      Consensus CDS
      CCDS89199.1
      UniProtKB/Swiss-Prot
      Q0VG32, Q52KL4, Q8C7F2, Q9D9R0
      UniProtKB/TrEMBL
      A4PBT3
      Related
      ENSMUSP00000157304.2, ENSMUST00000234316.2
      Conserved Domains (2) summary
      pfam05605
      Location:142 → 174
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      cl17238
      Location:35 → 77
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_026301.3 → NP_080577.1  E3 ubiquitin-protein ligase RNF125 isoform 1

      See identical proteins and their annotated locations for NP_080577.1

      Status: VALIDATED

      Source sequence(s)
      AC138611, AK050395, AK050462, BF148133
      Consensus CDS
      CCDS29088.1
      UniProtKB/Swiss-Prot
      Q9D9R0
      Related
      ENSMUSP00000058251.2, ENSMUST00000050004.3
      Conserved Domains (1) summary
      pfam05605
      Location:49 → 81
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      21077672..21120416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9R0.3 GenPept UniProtKB/Swiss-Prot:Q9D9R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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