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    Rexo1 REX1, RNA exonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 66932, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Rexo1provided by MGI
    Official Full Name
    REX1, RNA exonuclease 1provided by MGI
    Primary source
    MGI:MGI:1914182
    See related
    Ensembl:ENSMUSG00000047417 AllianceGenome:MGI:1914182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rex1; EloA-BP1; Tceb3bp1; 1700021P10Rik; 2610511M11Rik
    Summary
    Predicted to enable exonuclease activity. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.1), testis adult (RPKM 21.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80376759..80400624, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80540926..80564790, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene one cut domain, family member 3 Neighboring gene ATPase, class I, type 8B, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1124 Neighboring gene predicted gene, 31057 Neighboring gene STARR-positive B cell enhancer ABC_E10628 Neighboring gene STARR-positive B cell enhancer mm9_chr10:80032416-80032717 Neighboring gene Kruppel-like transcription factor 16 Neighboring gene STARR-positive B cell enhancer ABC_E11446 Neighboring gene predicted gene, 26710

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease 1 homolog
    Names
    REX1, RNA exonuclease 1 homolog
    elongin A binding protein 1
    transcription elongation factor B polypeptide 3 binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025852.4 → NP_080128.2  RNA exonuclease 1 homolog

      See identical proteins and their annotated locations for NP_080128.2

      Status: VALIDATED

      Source sequence(s)
      AC152058
      Consensus CDS
      CCDS24025.1
      UniProtKB/Swiss-Prot
      Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q7TT28, Q9DA29
      Related
      ENSMUSP00000049705.9, ENSMUST00000057910.16
      Conserved Domains (2) summary
      cd06145
      Location:1053 → 1201
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam15870
      Location:794 → 954
      EloA-BP1; ElonginA binding-protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80376759..80400624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513961.4 → XP_006514024.1  RNA exonuclease 1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006514024.1

      Conserved Domains (3) summary
      cd06145
      Location:1061 → 1209
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      PHA03307
      Location:150 → 461
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15870
      Location:794 → 962
      EloA-BP1; ElonginA binding-protein 1

    2. XM_011243531.3 → XP_011241833.1  RNA exonuclease 1 homolog isoform X3

      Conserved Domains (3) summary
      cd06145
      Location:1060 → 1208
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      PHA03307
      Location:150 → 461
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15870
      Location:794 → 961
      EloA-BP1; ElonginA binding-protein 1

    3. XM_011243530.3 → XP_011241832.1  RNA exonuclease 1 homolog isoform X1

      Conserved Domains (3) summary
      cd06145
      Location:1068 → 1216
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      PHA03307
      Location:150 → 461
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15870
      Location:794 → 969
      EloA-BP1; ElonginA binding-protein 1

    RNA

    1. XR_004936252.1 RNA Sequence

    2. XR_004936251.1 RNA Sequence

    3. XR_004936255.1 RNA Sequence

    4. XR_003948775.1 RNA Sequence

    5. XR_871724.3 RNA Sequence

    6. XR_004936253.1 RNA Sequence

    7. XR_004936254.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TT28.1 GenPept UniProtKB/Swiss-Prot:Q7TT28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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