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    Fbxo5 F-box protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 67141, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Fbxo5provided by MGI
    Official Full Name
    F-box protein 5provided by MGI
    Primary source
    MGI:MGI:1914391
    See related
    Ensembl:ENSMUSG00000019773 AllianceGenome:MGI:1914391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emi1; Fbxo31; 2510044I10Rik
    Summary
    Predicted to enable anaphase-promoting complex binding activity; protein kinase binding activity; and ubiquitin ligase inhibitor activity. Involved in regulation of mitotic cell cycle. Acts upstream of or within several processes, including female gamete generation; microtubule polymerization; and negative regulation of meiotic nuclear division. Located in cytoplasm and meiotic spindle. Is expressed in several structures, including brain ventricular layer; early conceptus; nephrogenic zone; oocyte; and rest of cerebellum marginal layer. Orthologous to human FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 31.2), liver E14.5 (RPKM 24.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A1; 10 1.91 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5749155..5755465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5799158..5805465, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47679 Neighboring gene STARR-seq mESC enhancer starr_25597 Neighboring gene predicted gene, 30617 Neighboring gene STARR-seq mESC enhancer starr_25595 Neighboring gene predicted gene, 53609 Neighboring gene STARR-positive B cell enhancer ABC_E3873 Neighboring gene STARR-positive B cell enhancer ABC_E3872 Neighboring gene mitochondrial translational release factor 1-like Neighboring gene regulator of G-protein signaling 17 Neighboring gene predicted gene, 18902

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Reimann JD, et al. Cell, 2001 Jun 1. PMID 11389834
    2. Cell cycle adaptations of embryonic stem cells. Ballabeni A, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084091, Free PMC Article
    3. Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). Marangos P, et al. J Cell Biol, 2007 Jan 1. PMID 17190794, Free PMC Article
    4. Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Lee H, et al. Mol Cell Biol, 2006 Jul. PMID 16809773, Free PMC Article
    5. Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. Shoji S, et al. EMBO J, 2006 Feb 22. PMID 16456547, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin ligase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA endoreduplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oocyte maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of biomineral tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within spindle assembly involved in female meiosis I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 5
    Names
    early mitotic inhibitor 1
    f-box only protein 31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429431.1 → NP_001416360.1  F-box only protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159325

    2. NM_025995.3 → NP_080271.2  F-box only protein 5 isoform 1

      See identical proteins and their annotated locations for NP_080271.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC159325
      Consensus CDS
      CCDS56683.1
      UniProtKB/Swiss-Prot
      Q7TSG3
      Related
      ENSMUSP00000019907.8, ENSMUST00000019907.8
      Conserved Domains (1) summary
      smart00256
      Location:232 → 264
      FBOX; A Receptor for Ubiquitination Targets

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      5749155..5755465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155959.1 → XP_036011852.1  F-box only protein 5 isoform X1

      Conserved Domains (2) summary
      smart00256
      Location:194 → 226
      FBOX; A Receptor for Ubiquitination Targets
      pfam01485
      Location:302 → 352
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSG3.1 GenPept UniProtKB/Swiss-Prot:Q7TSG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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