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    Prss54 serine protease 54 [ Mus musculus (house mouse) ]

    Gene ID: 70993, updated on 21-Apr-2024

    Summary

    Official Symbol
    Prss54provided by MGI
    Official Full Name
    serine protease 54provided by MGI
    Primary source
    MGI:MGI:1918243
    See related
    Ensembl:ENSMUSG00000048400 AllianceGenome:MGI:1918243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klkbl4; 4931432M23Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS54 (serine protease 54). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 70.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    8 D1; 8 47.12 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96285694..96302965, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95559066..95576337, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406B17 gene Neighboring gene coiled-coil domain containing 113 Neighboring gene STARR-seq mESC enhancer starr_22390 Neighboring gene G patch domain and KOW motifs pseudogene Neighboring gene STARR-seq mESC enhancer starr_22391 Neighboring gene predicted gene, 31518

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inactive serine protease 54
    Names
    plasma kallikrein-like protein 4
    protease, serine 54

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310539.1NP_001297468.1  inactive serine protease 54 precursor

      See identical proteins and their annotated locations for NP_001297468.1

      Status: VALIDATED

      Source sequence(s)
      AC102555, BC145787, BY716181
      Consensus CDS
      CCDS80916.1
      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Related
      ENSMUSP00000058859.7, ENSMUST00000052690.13
      Conserved Domains (1) summary
      cd00190
      Location:42253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96285694..96302965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531368.4XP_006531431.1  inactive serine protease 54 isoform X2

      See identical proteins and their annotated locations for XP_006531431.1

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_017312965.2XP_017168454.1  inactive serine protease 54 isoform X2

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_017312964.2XP_017168453.1  inactive serine protease 54 isoform X2

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_006531366.3XP_006531429.1  inactive serine protease 54 isoform X2

      See identical proteins and their annotated locations for XP_006531429.1

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      A6H685, B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:42253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_006531365.3XP_006531428.1  inactive serine protease 54 isoform X1

      UniProtKB/Swiss-Prot
      Q7M756
      UniProtKB/TrEMBL
      B7ZMX6
      Conserved Domains (1) summary
      cd00190
      Location:88299
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027640.1: Suppressed sequence

      Description
      NM_027640.1: This RefSeq has been removed because currently there is insufficient support for the transcript.