Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufa13provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase subunit A13provided by MGI
Primary source: MGI:MGI:1914434
See related: Ensembl:ENSMUSG00000036199 AllianceGenome:MGI:1914434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDA016; CGI-39; Grim19; GRIM-19; CI-B16.6; 2700054G14Rik
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and thyroid gland Hurthle cell carcinoma. Orthologous to several human genes including NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 81.9), testis adult (RPKM 75.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.03 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70346813..70355208, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (69894163..69902558, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortiondagger.
Title: GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortion†.
GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS.
Title: GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS.
Grim-19 plays a key role in mitochondrial steroidogenic acute regulatory protein stability and ligand-binding properties in Leydig cells.
Title: Grim-19 plays a key role in mitochondrial steroidogenic acute regulatory protein stability and ligand-binding properties in Leydig cells.
Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
Title: Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis.
Title: The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis.
GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions.
Title: GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions.
GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
Title: GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance.
Title: GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance.
the present study examined the distribution patterns of GRIM-19 in the adult C57BL/6 mouse brain
Title: Heterogeneity of GRIM-19 Expression in the Adult Mouse Brain.
The protein and mRNA levels of GRIM-19 were markedly decreased on Day 4 of pregnancy, but there was no change in GRIM-19 levels in a group of pseudopregnant mice. Overexpression of GRIM-19 decreased the adhesion rate of RL95-2-BeWo co-cultured spheroids and increased apoptosis.
Title: GRIM-19, a gene associated with retinoid-interferon-induced mortality, affects endometrial receptivity and embryo implantation.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial respirasome	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in respirasome	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH-ubiquinone oxidoreductase B16.6 subunit; cell death regulatory protein GRIM-19; complex I-B16.6; gene associated with retinoic and IFN-induced mortality 19 protein; gene associated with retinoic and interferon-induced mortality 19 protein; gene associated with retinoic-interferon-induced mortality 19 protein; genes associated with retinoid-IFN-induced mortality 19

NP_001369144.1

EC 7.1.1.2

NP_001408485.1

EC 7.1.1.2

NP_075801.1

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382215.1 → NP_001369144.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Status: VALIDATED

Source sequence(s)

AC158564

UniProtKB/Swiss-Prot

Q9DC98, Q9DCA1, Q9ERS2

Conserved Domains (1) summary

pfam06212
Location:5 → 128

GRIM-19; GRIM-19 protein
NM_001421556.1 → NP_001408485.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Status: VALIDATED

Source sequence(s)

AC158564

UniProtKB/Swiss-Prot

Q9DC98, Q9DCA1, Q9ERS2
NM_023312.3 → NP_075801.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

See identical proteins and their annotated locations for NP_075801.1

Status: VALIDATED

Source sequence(s)

AC158564

Consensus CDS

CCDS22353.1

UniProtKB/Swiss-Prot

Q9DC98, Q9DCA1, Q9ERS2

Related

ENSMUSP00000105796.4, ENSMUST00000110167.5

Conserved Domains (1) summary

pfam06212
Location:5 → 128

GRIM-19; GRIM-19 protein