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    Ppp1r12b protein phosphatase 1, regulatory subunit 12B [ Mus musculus (house mouse) ]

    Gene ID: 329251, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ppp1r12bprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Bprovided by MGI
    Primary source
    MGI:MGI:1916417
    See related
    Ensembl:ENSMUSG00000073557 AllianceGenome:MGI:1916417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mypt2; 1810037O03Rik; 9530009M10Rik
    Summary
    Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Predicted to be involved in signal transduction. Located in A band and Z disc. Orthologous to human PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 30.2), heart adult (RPKM 14.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E4; 1 58.24 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134682396..134883699, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134754658..134955963, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:136456618-136456805 Neighboring gene STARR-seq mESC enhancer starr_02340 Neighboring gene MGAT4 family, member E Neighboring gene STARR-seq mESC enhancer starr_02343 Neighboring gene lysine demethylase 5B Neighboring gene STARR-seq mESC enhancer starr_02345 Neighboring gene synaptotagmin II Neighboring gene predicted gene, 32670 Neighboring gene predicted gene, 57568 Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene predicted gene, 51748 Neighboring gene microRNA 5104b Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3. Hu T, et al. J Biol Chem, 2023 Apr. PMID 36889588, Free PMC Article
    2. Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function. Mizutani H, et al. Circ J, 2010 Jan. PMID 19966500
    3. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B. Liu K, et al. EBioMedicine, 2020 Nov. PMID 33096475, Free PMC Article
    4. Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations. Hughes JJ, et al. Am J Hum Genet, 2020 Jan 2. PMID 31883643, Free PMC Article
    5. Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. Arimura T, et al. J Biol Chem, 2001 Mar 2. PMID 11067852

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
      Title: The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
    2. Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3.
      Title: Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3.
    3. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
      Title: Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
    4. MYPT2 is truly the regulatory subunit of cardiac myosin phosphatase in-vivo and plays a significant role in modulating cardiac function.
      Title: Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in A band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 12B
    Names
    myosin phosphatase target subunit 2
    myosin phosphatase-targeting subunit 2
    protein phosphatase 1, regulatory (inhibitor) subunit 12B
    NP_001074776.1
    NP_001355756.1
    NP_001355758.1
    XP_006529770.1
    XP_006529776.1
    XP_017176766.1
    XP_017176767.1
    XP_017176768.1
    XP_036021781.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081307.2 → NP_001074776.1  protein phosphatase 1 regulatory subunit 12B isoform 1

      See identical proteins and their annotated locations for NP_001074776.1

      Status: VALIDATED

      Source sequence(s)
      AC117827, AC131591
      Consensus CDS
      CCDS35717.1
      UniProtKB/TrEMBL
      A6H644
      Related
      ENSMUSP00000131406.2, ENSMUST00000168381.8
      Conserved Domains (5) summary
      cd00204
      Location:85 → 269
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:219 → 269
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:875 → 981
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]

    2. NM_001368827.1 → NP_001355756.1  protein phosphatase 1 regulatory subunit 12B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117827, AC131591
      Consensus CDS
      CCDS87881.1
      UniProtKB/Swiss-Prot
      Q8BG95, Q8BXY7, Q9D8S6
      Related
      ENSMUSP00000047463.7, ENSMUST00000045665.13
      Conserved Domains (4) summary
      PHA03095
      Location:61 → 290
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:875 → 975
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    3. NM_001368829.1 → NP_001355758.1  protein phosphatase 1 regulatory subunit 12B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117827, AC131591
      Conserved Domains (4) summary
      PLN03192
      Location:1 → 89
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:48 → 79
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:53 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:707 → 807
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134682396..134883699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529713.5 → XP_006529776.1  protein phosphatase 1 regulatory subunit 12B isoform X6

      UniProtKB/TrEMBL
      A0A571BGD8
      Related
      ENSMUSP00000158804.2, ENSMUST00000238280.2
      Conserved Domains (1) summary
      pfam15898
      Location:85 → 185
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    2. XM_017321279.3 → XP_017176768.1  protein phosphatase 1 regulatory subunit 12B isoform X4

      Conserved Domains (6) summary
      PLN03192
      Location:1 → 89
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:48 → 79
      ANK; ANK repeat [structural motif]
      pfam04388
      Location:362 → 681
      Hamartin; Hamartin protein
      pfam12796
      Location:53 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:768 → 874
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      pfam17823
      Location:367 → 504
      DUF5585; Family of unknown function (DUF5585)

    3. XM_006529707.5 → XP_006529770.1  protein phosphatase 1 regulatory subunit 12B isoform X1

      Conserved Domains (6) summary
      PHA03095
      Location:61 → 290
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]
      pfam04388
      Location:530 → 849
      Hamartin; Hamartin protein
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:936 → 1042
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      pfam17823
      Location:535 → 672
      DUF5585; Family of unknown function (DUF5585)

    4. XM_036165888.1 → XP_036021781.1  protein phosphatase 1 regulatory subunit 12B isoform X5

      Conserved Domains (5) summary
      PLN03192
      Location:1 → 89
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:48 → 79
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:53 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:707 → 813
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl40436
      Location:442 → 494
      IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

    5. XM_017321277.3 → XP_017176766.1  protein phosphatase 1 regulatory subunit 12B isoform X2

      Conserved Domains (6) summary
      PHA03095
      Location:61 → 290
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]
      pfam04388
      Location:530 → 849
      Hamartin; Hamartin protein
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:936 → 1036
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      pfam17823
      Location:535 → 672
      DUF5585; Family of unknown function (DUF5585)

    6. XM_017321278.3 → XP_017176767.1  protein phosphatase 1 regulatory subunit 12B isoform X3

      Conserved Domains (5) summary
      PHA03095
      Location:61 → 290
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]
      pfam04388
      Location:530 → 849
      Hamartin; Hamartin protein
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam17823
      Location:535 → 672
      DUF5585; Family of unknown function (DUF5585)

    RNA

    1. XR_387177.5 RNA Sequence

      Related
      ENSMUST00000132025.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015606.4: Suppressed sequence

      Description
      NR_015606.4: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG95.2 GenPept UniProtKB/Swiss-Prot:Q8BG95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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