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    Rnf19b ring finger protein 19B [ Mus musculus (house mouse) ]

    Gene ID: 75234, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnf19bprovided by MGI
    Official Full Name
    ring finger protein 19Bprovided by MGI
    Primary source
    MGI:MGI:1922484
    See related
    Ensembl:ENSMUSG00000028793 AllianceGenome:MGI:1922484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ibrdc3; 4930534K13Rik; 4930555L03Rik
    Summary
    Predicted to enable ubiquitin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Located in cytolytic granule. Orthologous to human RNF19B (ring finger protein 19B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 168.3), ovary adult (RPKM 52.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 62.76 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128951871..128978319)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129058144..129084526)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E122 Neighboring gene adenylate kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E6222 Neighboring gene STARR-positive B cell enhancer ABC_E7990 Neighboring gene STARR-seq mESC enhancer starr_11473 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10260 Neighboring gene STARR-positive B cell enhancer ABC_E3516 Neighboring gene transmembrane protein 54 Neighboring gene hippocalcin Neighboring gene STARR-positive B cell enhancer ABC_E4669 Neighboring gene fibronectin type III domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model. Lawrence DW, et al. PLoS One, 2019. PMID 31539400, Free PMC Article
    2. Reduced inflammation and cytokine production in NKLAM deficient mice during Streptococcus pneumoniae infection. Lawrence DW, et al. PLoS One, 2018. PMID 29518136, Free PMC Article
    3. E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression. Lawrence DW, et al. Immunobiology, 2015 Jan. PMID 25182373, Free PMC Article
    4. E3 ubiquitin ligase NKLAM is a macrophage phagosome protein and plays a role in bacterial killing. Lawrence DW, et al. Cell Immunol, 2012 Sep. PMID 23085241, Free PMC Article
    5. E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity. Lawrence DW, et al. Cell Signal, 2016 Dec. PMID 27570112, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that natural killer lytic-associated molecule (NKLAM/RNF19b) plays a role in regulating the production of pro-inflammatory cytokines during viral infection.
      Title: Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model.
    2. E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression.
      Title: E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression.
    3. Data show that Natural Killer Lytic-Associated Molecule (NKLAM) is a component of macrophage phagosomes and is involved in macrophage bactericidal functions.
      Title: E3 ubiquitin ligase NKLAM is a macrophage phagosome protein and plays a role in bacterial killing.
    4. support the role for NKLAM in NK function both in vitro and in vivo.
      Title: Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytolytic granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytolytic granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF19B
    Names
    IBR domain containing 3
    IBR domain-containing protein 3
    natural killer lytic-associated molecule
    NP_001355692.1
    NP_083495.1
    XP_036020406.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368763.1 → NP_001355692.1  E3 ubiquitin-protein ligase RNF19B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS89829.1
      UniProtKB/Swiss-Prot
      A0AUN9, A2A7Q9, Q7TT05
      Related
      ENSMUSP00000030584.5, ENSMUST00000030584.11
      Conserved Domains (4) summary
      smart00647
      Location:184 → 248
      IBR; In Between Ring fingers
      pfam01485
      Location:280 → 318
      IBR; IBR domain, a half RING-finger domain
      cd16776
      Location:116 → 169
      RING-HC_RBR_RNF19B; RING finger, HC subclass, found in RING finger protein 19B (RNF19B) and similar proteins
      cl00570
      Location:344 → 433
      AzlC; AzlC protein

    2. NM_029219.2 → NP_083495.1  E3 ubiquitin-protein ligase RNF19B isoform 2

      See identical proteins and their annotated locations for NP_083495.1

      Status: VALIDATED

      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS51305.1
      UniProtKB/TrEMBL
      E9Q2L7
      Related
      ENSMUSP00000131373.2, ENSMUST00000168461.8
      Conserved Domains (4) summary
      smart00647
      Location:184 → 248
      IBR; In Between Ring fingers
      pfam01485
      Location:279 → 317
      IBR; IBR domain, a half RING-finger domain
      pfam13639
      Location:116 → 163
      zf-RING_2; Ring finger domain
      cl00570
      Location:343 → 432
      AzlC; AzlC protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      128951871..128978319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164513.1 → XP_036020406.1  E3 ubiquitin-protein ligase RNF19B isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A7Q9.2 GenPept UniProtKB/Swiss-Prot:A2A7Q9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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