Pde11a phosphodiesterase 11A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde11aprovided by MGI
Official Full Name: phosphodiesterase 11Aprovided by MGI
Primary source: MGI:MGI:3036251
See related: Ensembl:ENSMUSG00000075270 AllianceGenome:MGI:3036251
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm350; PDE11A1; 6330414F14Rik; A630086N24Rik
Summary: Predicted to enable cGMP binding activity and cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP-mediated signaling; negative regulation of cGMP-mediated signaling; and signal transduction. Predicted to be located in perikaryon. Is expressed in axial skeleton and nervous system. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 44.8 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (75816152..76169501, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (75985808..76339145, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme.
Title: The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme.
Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories.
Title: Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories.
A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.
Title: A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.
Deletion of PDE11A enhances remote long-term memory (LTM) for social odor recognition and social transmission of food preference despite eliminating or silencing recent LTM for those same social events. Measurement of a surrogate marker of neuronal activation suggests the recent LTM deficits observed in Pde11 knockout mice correspond with decreased activation of ventral CA1 relative to wild-type littermates.
Title: Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled.
In dorsal hippocampus and ventral hippocampus (VHIPP), lithium-responsive C57BL/6J and 129S6/SvEvTac mice show decreased PDE11A4 protein expression relative to lithium-unresponsive BALB/cJ mice. In VHIPP, C57BL/6J mice also show differences in PDE11A4 compartmentalization relative to BALB/cJ mice. In contrast, neither PDE2A nor PDE10A expression differ among the strains.
Title: PDE11A negatively regulates lithium responsivity.
PDE11A is a key regulator of the oxytocin pathway and membrane signaling, consistent with its pivotal role in regulating social behavior
Title: PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain.
The data of this study suggest PDE11A is selectively required for the proper consolidation of recognition and associative social memories.
Title: Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice.
PDE11A knockout mice show subtle psychiatric-disease-related deficits, including hyperactivity in an open field, increased sensitivity to the glutamate N-methyl-D-aspartate receptor antagonist MK-801, as well as deficits in social behaviors
Title: Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Names: cAMP and cGMP phosphodiesterase 11A

NP_001074502.1

EC 3.1.4.35

EC 3.1.4.53

XP_006499516.1

EC 3.1.4.35

EC 3.1.4.53

XP_006499517.1

EC 3.1.4.35

EC 3.1.4.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081033.3 → NP_001074502.1 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

See identical proteins and their annotated locations for NP_001074502.1

Status: VALIDATED

Source sequence(s)

AL772341, AL845373, AL929133

Consensus CDS

CCDS38152.1

UniProtKB/Swiss-Prot

A2AKR2, P0C1Q2

UniProtKB/TrEMBL

B2RY77

Related

ENSMUSP00000097572.4, ENSMUST00000099992.10

Conserved Domains (2) summary

smart00065
Location:217 → 380

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:663 → 898

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

75816152..76169501 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499454.3 → XP_006499517.1 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X2

UniProtKB/TrEMBL

B2RY77

Conserved Domains (2) summary

smart00065
Location:217 → 380

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:632 → 854

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_006499453.3 → XP_006499516.1 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1

UniProtKB/TrEMBL

B2RY77

Conserved Domains (2) summary

smart00065
Location:217 → 380

GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases

pfam00233
Location:663 → 885

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase