Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dync1li2provided by MGI
Official Full Name: dynein, cytoplasmic 1 light intermediate chain 2provided by MGI
Primary source: MGI:MGI:107738
See related: Ensembl:ENSMUSG00000035770 AllianceGenome:MGI:107738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LIC2; Dlic2; Dncli2; Dnclic2; C920003I06
Summary: Predicted to enable dynein heavy chain binding activity and identical protein binding activity. Acts upstream of or within centrosome localization and microtubule cytoskeleton organization. Predicted to be located in kinetochore. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome; late endosome; and lysosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 27.9), frontal lobe adult (RPKM 24.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (105144306..105170415, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (104417674..104443050, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that Par3 acts as a cortical factor that tethers microtubules through its association with LIC2 dynein.
Title: Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration.
Results suggest that dynein 2 light intermediate chain (D2LIC) is a bona fide subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo.
Title: Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
colocalizes_with centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
colocalizes_with late endosome	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytoplasmic dynein 1 light intermediate chain 2

Names: dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic, light intermediate chain 2; dynein, cytoplasmic, light intermediate polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013380.2 → NP_001013398.2 cytoplasmic dynein 1 light intermediate chain 2

See identical proteins and their annotated locations for NP_001013398.2

Status: VALIDATED

Source sequence(s)

AK140743, AK147899, BU850577, BY290848, CD351101

Consensus CDS

CCDS22579.1

UniProtKB/Swiss-Prot

Q3UGJ3, Q6PDL0

UniProtKB/TrEMBL

A0A1D5RM94

Related

ENSMUSP00000045480.7, ENSMUST00000041769.8

Conserved Domains (4) summary

cd00009
Location:46 → 100

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

pfam05783
Location:30 → 488

DLIC; Dynein light intermediate chain (DLIC)

pfam13257
Location:374 → 473

DUF4048; Domain of unknown function (DUF4048)

cl21455
Location:218 → 294

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

105144306..105170415 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530882.5 → XP_006530945.1 cytoplasmic dynein 1 light intermediate chain 2 isoform X3

UniProtKB/TrEMBL

A0A1D5RM94

Related

ENSMUSP00000148716.2, ENSMUST00000212230.2

Conserved Domains (1) summary

pfam05783
Location:30 → 474

DLIC; Dynein light intermediate chain (DLIC)
XM_006530881.5 → XP_006530944.1 cytoplasmic dynein 1 light intermediate chain 2 isoform X2

UniProtKB/TrEMBL

A0A1D5RM94

Conserved Domains (1) summary

pfam05783
Location:30 → 446

DLIC; Dynein light intermediate chain (DLIC)
XM_006530880.5 → XP_006530943.1 cytoplasmic dynein 1 light intermediate chain 2 isoform X1

UniProtKB/TrEMBL

A0A1D5RM94

Conserved Domains (1) summary

pfam05783
Location:30 → 460

DLIC; Dynein light intermediate chain (DLIC)
XM_006530883.5 → XP_006530946.1 cytoplasmic dynein 1 light intermediate chain 2 isoform X4

Conserved Domains (1) summary

pfam05783
Location:30 → 367

DLIC; Dynein light intermediate chain (DLIC)