U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Syt16 synaptotagmin XVI [ Mus musculus (house mouse) ]

    Gene ID: 238266, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Syt16provided by MGI
    Official Full Name
    synaptotagmin XVIprovided by MGI
    Primary source
    MGI:MGI:2673872
    See related
    Ensembl:ENSMUSG00000044912 AllianceGenome:MGI:2673872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syt14l; syt14r; Strep14
    Summary
    Enables identical protein binding activity and phospholipid binding activity. Predicted to be involved in exocytosis. Predicted to be integral component of membrane. Is expressed in nervous system. Orthologous to human SYT16 (synaptotagmin 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 19.0), cortex adult (RPKM 13.3) and 7 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    12 C3; 12 32.02 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (74044490..74314690)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73997624..74267916)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8489 Neighboring gene S100 calcium binding protein A11, pseudogene Neighboring gene small nuclear RNA activating complex, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_32482 Neighboring gene predicted gene, 40889 Neighboring gene RIKEN cDNA 1700086L19 gene Neighboring gene DNA binding protein with his-thr domain

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. Fukuda M. J Biochem, 2003 May. PMID 12801916
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    synaptotagmin-16
    Names
    synaptotagmin 14-like protein
    synaptotagmin XIV-related protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364281.1 → NP_001351210.1  synaptotagmin-16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      Conserved Domains (2) summary
      cd08389
      Location:359 → 482
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:515 → 652
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    2. NM_001364282.1 → NP_001351211.1  synaptotagmin-16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      Consensus CDS
      CCDS88352.1
      UniProtKB/Swiss-Prot
      Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41
      Related
      ENSMUSP00000158983.2, ENSMUST00000238790.2
      Conserved Domains (2) summary
      cd08389
      Location:344 → 467
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:500 → 637
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    3. NM_001364283.1 → NP_001351212.1  synaptotagmin-16 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      Conserved Domains (2) summary
      cd08389
      Location:239 → 362
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:395 → 532
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    4. NM_001364284.1 → NP_001351213.1  synaptotagmin-16 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      Conserved Domains (2) summary
      cd08389
      Location:219 → 342
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:375 → 512
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    5. NM_001364285.1 → NP_001351214.1  synaptotagmin-16 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      Conserved Domains (2) summary
      cd08389
      Location:239 → 362
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cl14603
      Location:395 → 430
      C2; C2 domain

    6. NM_001422970.1 → NP_001409899.1  synaptotagmin-16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591

    7. NM_001422971.1 → NP_001409900.1  synaptotagmin-16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      UniProtKB/Swiss-Prot
      Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41

    8. NM_001422972.1 → NP_001409901.1  synaptotagmin-16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      UniProtKB/Swiss-Prot
      Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41

    9. NM_001422973.1 → NP_001409902.1  synaptotagmin-16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158365, AC161591
      UniProtKB/Swiss-Prot
      Q3UVM4, Q6PGM6, Q7TN83, Q8BJ41

    10. NM_172804.3 → NP_766392.2  synaptotagmin-16 isoform 3

      See identical proteins and their annotated locations for NP_766392.2

      Status: VALIDATED

      Source sequence(s)
      AK137129, AV348245, BB074919
      Consensus CDS
      CCDS49089.1
      UniProtKB/Swiss-Prot
      Q7TN83
      Related
      ENSMUSP00000152623.2, ENSMUST00000221220.2
      Conserved Domains (2) summary
      cd08389
      Location:254 → 377
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:410 → 547
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      74044490..74314690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246702.2 → XP_030102562.1  synaptotagmin-16 isoform X1

      Conserved Domains (2) summary
      cd08389
      Location:359 → 482
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:515 → 652
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    2. XM_036157401.1 → XP_036013294.1  synaptotagmin-16 isoform X1

      Conserved Domains (2) summary
      cd08389
      Location:359 → 482
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:515 → 652
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    3. XM_017315058.2 → XP_017170547.1  synaptotagmin-16 isoform X1

      Conserved Domains (2) summary
      cd08389
      Location:359 → 482
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:515 → 652
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    4. XM_036157400.1 → XP_036013293.1  synaptotagmin-16 isoform X1

      Conserved Domains (2) summary
      cd08389
      Location:359 → 482
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:515 → 652
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN83.1 GenPept UniProtKB/Swiss-Prot:Q7TN83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous