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    Ptk2b PTK2 protein tyrosine kinase 2 beta [ Mus musculus (house mouse) ]

    Gene ID: 19229, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ptk2bprovided by MGI
    Official Full Name
    PTK2 protein tyrosine kinase 2 betaprovided by MGI
    Primary source
    MGI:MGI:104908
    See related
    Ensembl:ENSMUSG00000059456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PYK; Raf; CAKB; FAK2; PYK2; CADTK; CAKbe; FADK2; Raftk; CAKbeta; E430023O05Rik
    Expression
    Broad expression in frontal lobe adult (RPKM 53.4), cortex adult (RPKM 51.8) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptk2b in Genome Data Viewer
    Location:
    14 D1; 14 34.36 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66390706..66518549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66153257..66281100, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66772094..66899889, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase 2, cytoplasmic Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) Neighboring gene predicted gene, 52098 Neighboring gene predicted gene, 52099 Neighboring gene RIKEN cDNA 1700001G11 gene Neighboring gene tripartite motif-containing 35 Neighboring gene predicted gene, 41183

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in marginal zone B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of NMDA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of inositol trisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of leukocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-tyrosine kinase 2-beta
    Names
    CAK-beta
    calcium-dependent tyrosine kinase
    calcium-regulated non-receptor proline-rich tyrosine kinase
    cell adhesion kinase beta
    cellular adhesion kinase beta
    focal adhesion kinase 2
    proline-rich tyrosine kinase 2
    related adhesion focal tyrosine kinase
    NP_001155837.1
    NP_001155838.1
    NP_001347162.1
    NP_766086.2
    XP_017171415.1
    XP_017171416.1
    XP_017171417.1
    XP_017171418.1
    XP_017171419.1
    XP_036014417.1
    XP_036014418.1
    XP_036014419.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162365.1NP_001155837.1  protein-tyrosine kinase 2-beta isoform 2

      See identical proteins and their annotated locations for NP_001155837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC140329, AK150105, BY204086, CD775714
      Consensus CDS
      CCDS49525.1
      UniProtKB/TrEMBL
      Q3UDE9
      Related
      ENSMUSP00000106750.2, ENSMUST00000111121.2
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:868997
      Focal_AT; Focal adhesion targeting region
    2. NM_001162366.2NP_001155838.1  protein-tyrosine kinase 2-beta isoform 1

      See identical proteins and their annotated locations for NP_001155838.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC140329, AI181574, AK150105, BY203814, BY206153, CD775714
      Consensus CDS
      CCDS49526.1
      UniProtKB/Swiss-Prot
      Q9QVP9
      UniProtKB/TrEMBL
      K7QD41, Q3UDE9
      Related
      ENSMUSP00000022622.8, ENSMUST00000022622.14
      Conserved Domains (4) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region
    3. NM_001360233.1NP_001347162.1  protein-tyrosine kinase 2-beta isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC140329, AI181574, AK150105, BY203814, CD775714
      Consensus CDS
      CCDS49526.1
      Related
      ENSMUSP00000137008.2, ENSMUST00000178730.8
      Conserved Domains (4) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region
    4. NM_172498.3NP_766086.2  protein-tyrosine kinase 2-beta isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AA462640, AC140329, AK150105, BY204086, CD775714
      Consensus CDS
      CCDS27220.1
      UniProtKB/TrEMBL
      E9Q2A6, Q3UDE9
      Related
      ENSMUSP00000086661.3, ENSMUST00000089250.9
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:830959
      Focal_AT; Focal adhesion targeting region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      66390706..66518549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315926.2XP_017171415.1  protein-tyrosine kinase 2-beta isoform X1

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8831012
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
    2. XM_017315930.3XP_017171419.1  protein-tyrosine kinase 2-beta isoform X2

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:841970
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
    3. XM_036158524.1XP_036014417.1  protein-tyrosine kinase 2-beta isoform X1

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8831012
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
    4. XM_036158525.1XP_036014418.1  protein-tyrosine kinase 2-beta isoform X1

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8831012
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
    5. XM_017315929.2XP_017171418.1  protein-tyrosine kinase 2-beta isoform X1

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8831012
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
    6. XM_017315927.2XP_017171416.1  protein-tyrosine kinase 2-beta isoform X1

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8831012
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
    7. XM_036158526.1XP_036014419.1  protein-tyrosine kinase 2-beta isoform X1

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8831012
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
    8. XM_017315928.2XP_017171417.1  protein-tyrosine kinase 2-beta isoform X1

      Conserved Domains (5) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8831012
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:39137
      FERM_N_2; FERM N-terminal domain
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