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    Kif5a kinesin family member 5A [ Mus musculus (house mouse) ]

    Gene ID: 16572, updated on 16-Oct-2021

    Summary

    Official Symbol
    Kif5aprovided by MGI
    Official Full Name
    kinesin family member 5Aprovided by MGI
    Primary source
    MGI:MGI:109564
    See related
    Ensembl:ENSMUSG00000074657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Khc; Kns; Kif5; mKIAA4086; D10Bwg0738e
    Expression
    Biased expression in cortex adult (RPKM 286.9), frontal lobe adult (RPKM 199.5) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kif5a in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127061564..127102217, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127225695..127266348, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (126662751..126700419, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene deltex 3, E3 ubiquitin ligase Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene predicted gene, 40800 Neighboring gene dynactin 2 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4086

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in central region of growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of kinesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin heavy chain isoform 5A; kinesin heavy chain
    Names
    NKHC
    kinesin heavy chain neuron-specific 1
    neuronal kinesin heavy chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039000.4NP_001034089.1  kinesin heavy chain isoform 5A

      See identical proteins and their annotated locations for NP_001034089.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer and the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK140769, AK147707, BC028563, BC058396
      Consensus CDS
      CCDS24233.1
      UniProtKB/Swiss-Prot
      P33175
      UniProtKB/TrEMBL
      Q3US62
      Related
      ENSMUSP00000096775.4, ENSMUST00000099172.5
      Conserved Domains (3) summary
      COG1196
      Location:412759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01369
      Location:7327
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
      pfam17380
      Location:630902
      DUF5401; Family of unknown function (DUF5401)
    2. NM_008447.4NP_032473.2  kinesin heavy chain isoform 5A

      See identical proteins and their annotated locations for NP_032473.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC144852, AK140769, BC058396
      Consensus CDS
      CCDS24233.1
      UniProtKB/Swiss-Prot
      P33175
      UniProtKB/TrEMBL
      Q3US62
      Related
      ENSMUSP00000151402.2, ENSMUST00000217895.2
      Conserved Domains (3) summary
      COG1196
      Location:412759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01369
      Location:7327
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
      pfam17380
      Location:630902
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127061564..127102217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244919.1XP_030100779.1  kinesin heavy chain isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:412759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01369
      Location:7327
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
      pfam17380
      Location:630902
      DUF5401; Family of unknown function (DUF5401)
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