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    Ankrd44 ankyrin repeat domain 44 [ Mus musculus (house mouse) ]

    Gene ID: 329154, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd44provided by MGI
    Official Full Name
    ankyrin repeat domain 44provided by MGI
    Primary source
    MGI:MGI:3045243
    See related
    Ensembl:ENSMUSG00000052331 AllianceGenome:MGI:3045243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP6-ARS-B; A130096K20; 4930444A19Rik; E130014H08Rik
    Summary
    Orthologous to human ANKRD44 (ankyrin repeat domain 44). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 10.4), lung adult (RPKM 10.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C1.2; 1 27.7 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (54684499..54968142, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (54645340..54928983, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene post-GPI attachment to proteins 1 Neighboring gene predicted gene, 51623 Neighboring gene STARR-seq mESC enhancer starr_00937 Neighboring gene predicted gene, 19637 Neighboring gene RIKEN cDNA 4930444A19 gene Neighboring gene STARR-seq mESC enhancer starr_00938 Neighboring gene STARR-positive B cell enhancer ABC_E4315 Neighboring gene STARR-positive B cell enhancer mm9_chr1:54898672-54898972 Neighboring gene STARR-seq mESC enhancer starr_00940 Neighboring gene STARR-positive B cell enhancer ABC_E11069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:54970246-54970399 Neighboring gene STARR-positive B cell enhancer ABC_E11070 Neighboring gene STARR-seq mESC enhancer starr_00941 Neighboring gene STARR-seq mESC enhancer starr_00942 Neighboring gene STARR-seq mESC enhancer starr_00943 Neighboring gene splicing factor 3b, subunit 1 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene coenzyme Q10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
    Names
    ankyrin repeat domain-containing protein 44
    serine/threonine-protein phosphatase 6 regulatory subunit ARS-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081433.3 → NP_001074902.2  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

      See identical proteins and their annotated locations for NP_001074902.2

      Status: VALIDATED

      Source sequence(s)
      AC151572, AC160472, AC166111, BF461794
      Consensus CDS
      CCDS35566.2
      UniProtKB/Swiss-Prot
      B2RXN6, B2RXR6, B7ZWK8
      Related
      ENSMUSP00000137616.2, ENSMUST00000179030.8
      Conserved Domains (6) summary
      cd00204
      Location:134 → 259
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:272 → 304
      Ank; Ankyrin repeat
      pfam12796
      Location:177 → 269
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:672 → 723
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:722 → 779
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:140 → 170
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      54684499..54968142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254997.1 → XP_030110857.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X9

      Related
      ENSMUSP00000136802.2, ENSMUST00000178226.3
      Conserved Domains (2) summary
      PHA03095
      Location:14 → 287
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:68 → 98
      ANK; ANK repeat [structural motif]

    2. XM_030254994.1 → XP_030110854.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X6

      Conserved Domains (2) summary
      PHA03095
      Location:14 → 287
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:68 → 98
      ANK; ANK repeat [structural motif]

    3. XM_006496071.4 → XP_006496134.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X2

      Conserved Domains (3) summary
      PHA03095
      Location:86 → 359
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:140 → 170
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:12 → 104
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006496073.4 → XP_006496136.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X5

      UniProtKB/TrEMBL
      E9QNQ2
      Related
      ENSMUSP00000040327.10, ENSMUST00000044359.16
      Conserved Domains (3) summary
      PHA03095
      Location:86 → 359
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:140 → 170
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:12 → 104
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_006496070.4 → XP_006496133.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1

      Conserved Domains (3) summary
      PHA03095
      Location:86 → 359
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:140 → 170
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:12 → 104
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_030254996.1 → XP_030110856.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X7

      Conserved Domains (2) summary
      PHA03095
      Location:14 → 287
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:68 → 98
      ANK; ANK repeat [structural motif]

    7. XM_036165753.1 → XP_036021646.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X8

      Conserved Domains (3) summary
      PHA03095
      Location:61 → 334
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:115 → 145
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:2 → 79
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_030254992.1 → XP_030110852.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X4

      Conserved Domains (3) summary
      PHA03095
      Location:61 → 334
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:115 → 145
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:2 → 79
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_011238538.3 → XP_011236840.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X3

      Conserved Domains (3) summary
      PHA03095
      Location:61 → 334
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:115 → 145
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:2 → 79
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_030254995.2 → XP_030110855.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X6

      Conserved Domains (2) summary
      PHA03095
      Location:14 → 287
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:68 → 98
      ANK; ANK repeat [structural motif]

    11. XM_030254991.2 → XP_030110851.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X3

      Conserved Domains (3) summary
      PHA03095
      Location:61 → 334
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:115 → 145
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:2 → 79
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RXR6.1 GenPept UniProtKB/Swiss-Prot:B2RXR6

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