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    Taf4b TATA-box binding protein associated factor 4b [ Mus musculus (house mouse) ]

    Gene ID: 72504, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Taf4bprovided by MGI
    Official Full Name
    TATA-box binding protein associated factor 4bprovided by MGI
    Primary source
    MGI:MGI:2152345
    See related
    Ensembl:ENSMUSG00000054321 AllianceGenome:MGI:2152345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    105kDa; Taf2c2; TAFII105; TAFII-105; 2610524B04Rik; 4932409F03Rik
    Summary
    Predicted to enable DNA binding activity and NF-kappaB binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of stem cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Is expressed in genitourinary system and tail. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Orthologous to human TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 3.7), testis adult (RPKM 2.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 A1; 18 8.28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (14916302..15035160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (14783201..14960424)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene SS18, subunit of BAF chromatin remodeling complex Neighboring gene predicted gene, 24924 Neighboring gene STARR-seq mESC enhancer starr_43875 Neighboring gene STARR-seq mESC enhancer starr_43877 Neighboring gene proteasome subunit alpha 8 Neighboring gene STARR-positive B cell enhancer ABC_E1951 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_43878 Neighboring gene RIKEN cDNA 4930543D07 gene Neighboring gene SUMO/sentrin specific peptidase 5 pseudogene Neighboring gene predicted gene, 54035

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dynamic and regulated TAF gene expression during mouse embryonic germ cell development. Gura MA, et al. PLoS Genet, 2020 Jan. PMID 31914128, Free PMC Article
    2. Ovarian granulosa cell survival and proliferation requires the gonad-selective TFIID subunit TAF4b. Voronina E, et al. Dev Biol, 2007 Mar 15. PMID 17207475, Free PMC Article
    3. TAF4b, a TBP associated factor, is required for oocyte development and function. Falender AE, et al. Dev Biol, 2005 Dec 15. PMID 16289522
    4. Redundant role of tissue-selective TAF(II)105 in B lymphocytes. Freiman RN, et al. Mol Cell Biol, 2002 Sep. PMID 12192054, Free PMC Article
    5. Enhanced apoptosis of B and T lymphocytes in TAFII105 dominant-negative transgenic mice is linked to nuclear factor-kappa B. Silkov A, et al. J Biol Chem, 2002 May 17. PMID 11856754

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAF4b transcription networks regulating early oocyte differentiation.
      Title: TAF4b transcription networks regulating early oocyte differentiation.
    2. Taf4b mRNA and protein expression is differentially regulated during embryonic germ cell development.
      Title: Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.
    3. TAF4b-deficient spermatogenic progenitor cells display a tendency for differentiation at the expense of self-renewal.
      Title: TAF4b is required for mouse spermatogonial stem cell development.
    4. Data show that the TFIID subunit TAF4 is essential to restrain the growth promoting properties of collagen 6A3 (Col6a3).
      Title: TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.
    5. These data reveal a novel TAF4b function in orchestrating the correct timing of germ cell cyst breakdown and establishment of the primordial follicle reserve during a critical window of development.
      Title: TAF4b promotes mouse primordial follicle assembly and oocyte survival.
    6. These data highlight the novel response of the general transcription factor TAF4B to estrogen in the normal ovary and during ovarian tumor progression in the mouse.
      Title: Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.
    7. Taf4b binds Oct4 in vitro and cooperates to regulate a subset of genes in embryonic stem cells.
      Title: TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation.
    8. Small interfering RNA knockdown of Taf4b results in decreased cell proliferation and altered osteogenic differentiation in primary mouse embryonic maxillary mesenchymal cells.
      Title: Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.
    9. linked to the posttranscriptional control of ovarian gene expression
      Title: Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice.
    10. role of TAF(II)105 in B lymphocytes
      Title: Redundant role of tissue-selective TAF(II)105 in B lymphocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 4B
    Names
    TAF(II)105
    TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105 kDa
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
    transcription initiation factor TFIID 105 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100449.2 → NP_001093919.1  transcription initiation factor TFIID subunit 4B isoform 1

      See identical proteins and their annotated locations for NP_001093919.1

      Status: VALIDATED

      Source sequence(s)
      AC102692, AC125091, AC133172
      Consensus CDS
      CCDS50227.1
      UniProtKB/Swiss-Prot
      G5E8Z2
      UniProtKB/TrEMBL
      A0A3B2W725
      Related
      ENSMUSP00000126909.2, ENSMUST00000169862.2
      Conserved Domains (2) summary
      pfam05236
      Location:610 → 850
      TAF4; Transcription initiation factor TFIID component TAF4 family
      pfam07531
      Location:257 → 343
      TAFH; NHR1 homology to TAF

    2. NM_001369357.1 → NP_001356286.1  transcription initiation factor TFIID subunit 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102692, AC125091, AC133172
      Consensus CDS
      CCDS89195.1
      UniProtKB/Swiss-Prot
      G5E8Z2
      UniProtKB/TrEMBL
      A0A3Q4EGS4
      Related
      ENSMUSP00000157354.2, ENSMUST00000234789.2
      Conserved Domains (3) summary
      PRK14950
      Location:2 → 91
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam05236
      Location:605 → 845
      TAF4; Transcription initiation factor TFIID component TAF4 family
      pfam07531
      Location:257 → 343
      TAFH; NHR1 homology to TAF

    3. NM_001369358.1 → NP_001356287.1  transcription initiation factor TFIID subunit 4B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102692, AC125091, AC133172
      UniProtKB/Swiss-Prot
      G5E8Z2
      Conserved Domains (4) summary
      COG5665
      Location:137 → 318
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      PRK14950
      Location:2 → 91
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam05236
      Location:564 → 804
      TAF4; Transcription initiation factor TFIID component TAF4 family
      cl02658
      Location:253 → 302
      TAFH; NHR1 homology to TAF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      14916302..15035160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E8Z2.2 GenPept UniProtKB/Swiss-Prot:G5E8Z2

    Gene LinkOut

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