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    Vwf Von Willebrand factor [ Mus musculus (house mouse) ]

    Gene ID: 22371, updated on 3-Aug-2021

    Summary

    Official Symbol
    Vwfprovided by MGI
    Official Full Name
    Von Willebrand factorprovided by MGI
    Primary source
    MGI:MGI:98941
    See related
    Ensembl:ENSMUSG00000001930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VWD; F8VWF; AI551257; C630030D09; 6820430P06Rik; B130011O06Rik
    Expression
    Biased expression in lung adult (RPKM 49.3), heart adult (RPKM 9.7) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Vwf in Genome Data Viewer
    Location:
    6 F3; 6 59.32 cM
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125529911..125663642)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125552948..125686679)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125502981..125636695)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26728 Neighboring gene CD9 antigen Neighboring gene predicted gene, 33144 Neighboring gene anoctamin 2 Neighboring gene predicted gene, 38898 Neighboring gene predicted gene, 33202

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables immunoglobulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-substrate adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hemostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT acts_upstream_of_or_within platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Weibel-Palade body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    von Willebrand factor
    Names
    Von Willebrand factor homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011708.4NP_035838.3  von Willebrand factor precursor

      See identical proteins and their annotated locations for NP_035838.3

      Status: VALIDATED

      Source sequence(s)
      AC153580, AY208897, BF662502, BI133662
      Consensus CDS
      CCDS20552.1
      UniProtKB/Swiss-Prot
      Q8CIZ8
      UniProtKB/TrEMBL
      E9QPU1
      Related
      ENSMUSP00000107873.3, ENSMUST00000112254.8
      Conserved Domains (11) summary
      smart00041
      Location:27272808
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:24312494
      VWC; von Willebrand factor (vWF) type C domain
      smart00216
      Location:377540
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:12771449
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:10531127
      C8; This domain contains 8 conserved cysteine residues
      pfam00092
      Location:14981658
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:35179
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:295348
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:580648
      C8; C8 domain
      pfam16164
      Location:11981276
      VWA_N2; VWA N-terminal
      cl17735
      Location:25822644
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125529911..125663642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505918.5XP_006505981.1  von Willebrand factor isoform X1

      Conserved Domains (12) summary
      smart00041
      Location:26632744
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:23672430
      VWC; von Willebrand factor (vWF) type C domain
      smart00216
      Location:313476
      VWD; von Willebrand factor (vWF) type D domain
      smart00327
      Location:12131385
      VWA; von Willebrand factor (vWF) type A domain
      smart00832
      Location:9891063
      C8; This domain contains 8 conserved cysteine residues
      cl17735
      Location:25182580
      VWC; von Willebrand factor type C domain
      pfam00092
      Location:14341594
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:803947
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:231284
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:520584
      C8; C8 domain
      pfam16164
      Location:11341212
      VWA_N2; VWA N-terminal
      cl02516
      Location:19113
      VWD; von Willebrand factor type D domain
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