Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pde8b phosphodiesterase 8B [ Mus musculus (house mouse) ]

    Gene ID: 218461, updated on 14-Aug-2021

    Summary

    Official Symbol
    Pde8bprovided by MGI
    Official Full Name
    phosphodiesterase 8Bprovided by MGI
    Primary source
    MGI:MGI:2443999
    See related
    Ensembl:ENSMUSG00000021684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230331L10Rik; C030047E14Rik
    Expression
    Biased expression in adrenal adult (RPKM 17.9), cortex adult (RPKM 8.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pde8b in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95160613..95386904, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95024105..95250401, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (95794060..96020259, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41024 Neighboring gene WD repeat domain 41 Neighboring gene predicted gene, 48350 Neighboring gene predicted gene, 41025 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene predicted gene, 22661 Neighboring gene zinc finger, BED type containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
    Names
    cell proliferation-inducing gene 22 protein
    NP_001164140.1
    NP_001333711.1
    NP_001360932.1
    NP_001360933.1
    NP_001360934.1
    NP_001360935.1
    NP_001360936.1
    NP_758467.2
    XP_006517650.1
    XP_006517651.1
    XP_006517652.1
    XP_006517654.1
    XP_006517657.1
    XP_011242951.1
    XP_011242952.1
    XP_011242953.1
    XP_017170982.1
    XP_017170983.1
    XP_030103093.1
    XP_030103094.1
    XP_030103095.1
    XP_030103096.1
    XP_036013910.1
    XP_036013911.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170669.1NP_001164140.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK045991, BG695121
      Consensus CDS
      CCDS49331.1
      UniProtKB/TrEMBL
      E9PYP0
      Related
      ENSMUSP00000124068.2, ENSMUST00000162292.8
      Conserved Domains (3) summary
      PHA02597
      Location:158311
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:517764
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:147
      PDE8; PDE8 phosphodiesterase
    2. NM_001346782.1NP_001333711.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123034, AC134439, AC147108
      Consensus CDS
      CCDS84052.1
      UniProtKB/TrEMBL
      E9PX38
      Related
      ENSMUSP00000124704.2, ENSMUST00000162153.9
    3. NM_001374003.1NP_001360932.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123034, AC134439, AC147108
      Related
      ENSMUSP00000128987.2, ENSMUST00000172104.8
      Conserved Domains (4) summary
      COG2202
      Location:167375
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:147
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:614861
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:280377
      PAS_9; PAS domain
    4. NM_001374004.1NP_001360933.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123034, AC134439, AC147108
      Related
      ENSMUSP00000070465.8, ENSMUST00000067082.14
      Conserved Domains (4) summary
      COG2202
      Location:166374
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:147
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:613860
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:279376
      PAS_9; PAS domain
    5. NM_001374005.1NP_001360934.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC123034, AC134439, AC147108
      Conserved Domains (2) summary
      PHA02597
      Location:54207
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:413660
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    6. NM_001374006.1NP_001360935.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC123034, AC134439, AC147108
      Conserved Domains (2) summary
      PHA02597
      Location:53206
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:412659
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    7. NM_001374007.1NP_001360936.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC123034, AC134439, AC147108
      Conserved Domains (3) summary
      COG2202
      Location:63274
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:510757
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:176273
      PAS_9; PAS domain
    8. NM_172263.2NP_758467.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK083166, BE860708, BG695121, BY244338, CD806392
      Consensus CDS
      CCDS49332.1
      UniProtKB/TrEMBL
      E9PXX4, Q8BI47
      Related
      ENSMUSP00000124409.2, ENSMUST00000162412.8
      Conserved Domains (4) summary
      smart00091
      Location:168212
      PAS; PAS domain
      COG2202
      Location:62212
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:459706
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:174227
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      95160613..95386904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247236.2XP_030103096.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

      Conserved Domains (2) summary
      pfam00233
      Location:430677
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:96193
      PAS_9; PAS domain
    2. XM_030247233.2XP_030103093.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

      Conserved Domains (3) summary
      COG2202
      Location:87295
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:534781
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:200297
      PAS_9; PAS domain
    3. XM_036158017.1XP_036013910.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X10

      Conserved Domains (1) summary
      pfam00233
      Location:383630
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. XM_011244649.4XP_011242951.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

      See identical proteins and their annotated locations for XP_011242951.1

      Conserved Domains (3) summary
      COG2202
      Location:43254
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:490737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:156253
      PAS_9; PAS domain
    5. XM_006517594.5XP_006517657.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

      See identical proteins and their annotated locations for XP_006517657.1

      Conserved Domains (3) summary
      COG2202
      Location:43254
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:490737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:156253
      PAS_9; PAS domain
    6. XM_030247235.2XP_030103095.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

      Conserved Domains (2) summary
      pfam00233
      Location:430677
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:96193
      PAS_9; PAS domain
    7. XM_011244650.4XP_011242952.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

      Conserved Domains (2) summary
      pfam00233
      Location:430677
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:96193
      PAS_9; PAS domain
    8. XM_030247234.2XP_030103094.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

      Conserved Domains (3) summary
      PHA02597
      Location:157310
      30.2; hypothetical protein; Provisional
      pfam08629
      Location:147
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:516763
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    9. XM_006517591.5XP_006517654.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

      Conserved Domains (3) summary
      COG2202
      Location:86294
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:533780
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:199296
      PAS_9; PAS domain
    10. XM_036158018.1XP_036013911.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

      Conserved Domains (2) summary
      pfam00233
      Location:376623
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:42139
      PAS_9; PAS domain
    11. XM_017315494.3XP_017170983.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X12

      Conserved Domains (2) summary
      pfam00233
      Location:326573
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:4295
      PAS_9; PAS domain
    12. XM_011244651.4XP_011242953.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

      Conserved Domains (2) summary
      pfam00233
      Location:376623
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:42139
      PAS_9; PAS domain
    13. XM_017315493.3XP_017170982.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X9

      Conserved Domains (2) summary
      PHA02597
      Location:34187
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:393640
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    14. XM_006517588.5XP_006517651.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

      Conserved Domains (2) summary
      pfam08629
      Location:147
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:566813
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    15. XM_006517587.5XP_006517650.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

      UniProtKB/TrEMBL
      E9Q8J6
      Related
      ENSMUSP00000022192.6, ENSMUST00000022192.12
      Conserved Domains (2) summary
      pfam08629
      Location:147
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:567814
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    16. XM_006517589.5XP_006517652.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

      Conserved Domains (4) summary
      COG2202
      Location:167317
      PAS; PAS domain [Signal transduction mechanisms]
      pfam08629
      Location:147
      PDE8; PDE8 phosphodiesterase
      pfam00233
      Location:564811
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:280333
      PAS_9; PAS domain
    Support Center