Sik2 salt inducible kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sik2provided by MGI
Official Full Name: salt inducible kinase 2provided by MGI
Primary source: MGI:MGI:2445031
See related: Ensembl:ENSMUSG00000037112 AllianceGenome:MGI:2445031
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Snf1lk2; G630080D20Rik
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and regulation of insulin receptor signaling pathway. Acts upstream of or within insulin receptor signaling pathway and protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 30.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.75 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (50800944..50920432, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (50889644..51009132, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury.
Title: Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury.
SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
Title: SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
Salt inducible kinases 2 and 3 are required for thymic T cell development.
Title: Salt inducible kinases 2 and 3 are required for thymic T cell development.
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
Title: Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
Title: Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
Title: Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
Salt-inducible Kinases Are Critical Determinants of Female Fertility.
Title: Salt-inducible Kinases Are Critical Determinants of Female Fertility.
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Title: Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Silencing Sik2 further diminished SIRT3 activity and enhanced acetylation of PDHA1 K83 level. Reconstruction of SIRT3 restored PDH activity and thermogenic markers expression in differentiated brown adipocytes from SIRT3 knockout (KO) mice.
Title: Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions.
hippocampal SIK2-CRTC1 pathway is involved in the pathogenesis of depression.
Title: Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit193 (e-PCR), detects polymorphism
- UniSTS:131750

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription from RNA polymerase II promoter by glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription from RNA polymerase II promoter by glucose	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase SIK2

Names: SIK-2; SNF1-like kinase 2; salt induceable kinase 2; salt-inducible protein kinase 2; serine/threonine-protein kinase SNF1-like kinase 2

NP_001391943.1

EC 2.7.11.1

NP_001391944.1

EC 2.7.11.1

NP_848825.2

EC 2.7.11.1

XP_006510330.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405014.1 → NP_001391943.1 serine/threonine-protein kinase SIK2 isoform 2

Status: VALIDATED

Source sequence(s)

AC103406

UniProtKB/TrEMBL

H3BKG1

Related

ENSMUSP00000135376.2, ENSMUST00000176663.8
NM_001405015.1 → NP_001391944.1 serine/threonine-protein kinase SIK2 isoform 3

Status: VALIDATED

Source sequence(s)

AC103406
NM_178710.4 → NP_848825.2 serine/threonine-protein kinase SIK2 isoform 1

See identical proteins and their annotated locations for NP_848825.2

Status: VALIDATED

Source sequence(s)

AC103406

Consensus CDS

CCDS40627.1

UniProtKB/Swiss-Prot

Q8CFH6

UniProtKB/TrEMBL

F8VPT7

Related

ENSMUSP00000038761.11, ENSMUST00000041375.11

Conserved Domains (3) summary

smart00220
Location:20 → 271

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14409
Location:297 → 341

UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)

cd14071
Location:19 → 271

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

50800944..50920432 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510267.3 → XP_006510330.1 serine/threonine-protein kinase SIK2 isoform X2

UniProtKB/Swiss-Prot

Q8CFH6

Conserved Domains (2) summary

cd14409
Location:297 → 341

UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)

cd14071
Location:19 → 271

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases