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    Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 109294, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Prex2provided by MGI
    Official Full Name
    phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2provided by MGI
    Primary source
    MGI:MGI:1923385
    See related
    Ensembl:ENSMUSG00000048960 AllianceGenome:MGI:1923385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Depdc2; P-Rex2; D430013K02; 6230420N16Rik; C030045D06Rik
    Summary
    Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase signaling. Located in plasma membrane. Is expressed in brain ventricular layer and gut. Human ortholog(s) of this gene implicated in Klatskin's tumor. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 9.2), bladder adult (RPKM 4.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 A2; 1 2.57 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (11063496..11373907)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (10993273..11303683)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00189 Neighboring gene STARR-seq mESC enhancer starr_00190 Neighboring gene STARR-seq mESC enhancer starr_00191 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 pseudogene Neighboring gene predicted gene 28659 Neighboring gene STARR-seq mESC enhancer starr_00193 Neighboring gene STARR-seq mESC enhancer starr_00195 Neighboring gene predicted gene, 24173 Neighboring gene STARR-seq mESC enhancer starr_00196 Neighboring gene STARR-seq mESC enhancer starr_00198 Neighboring gene STARR-seq mESC enhancer starr_00199 Neighboring gene STARR-seq mESC enhancer starr_00200 Neighboring gene RIKEN cDNA A830018L16 gene Neighboring gene STARR-seq mESC enhancer starr_00202 Neighboring gene STARR-seq mESC enhancer starr_00204 Neighboring gene STARR-seq mESC enhancer starr_00208 Neighboring gene STARR-seq mESC enhancer starr_00209 Neighboring gene STARR-seq mESC enhancer starr_00210 Neighboring gene STARR-seq mESC enhancer starr_00211 Neighboring gene STARR-seq mESC enhancer starr_00212 Neighboring gene predicted gene, 30898

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain. Fu Q, et al. Mol Pain, 2022 Jan-Dec. PMID 35083941, Free PMC Article
    2. P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina. Sherry DM, et al. BMC Neurosci, 2013 Jul 11. PMID 23844743, Free PMC Article
    3. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. Jackson C, et al. PLoS One, 2010 Aug 4. PMID 20694145, Free PMC Article
    4. Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma. Lissanu Deribe Y, et al. Proc Natl Acad Sci U S A, 2016 Mar 1. PMID 26884185, Free PMC Article
    5. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Donald S, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18334636, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain.
      Title: P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain.
    2. complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
      Title: Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma.
    3. P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis
      Title: Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
    4. This study demonistrated that the P-Rex2, a GEF that specifically activates Rac small GTPases, is expressed in a cell- and synapse-specific manner in the retina.
      Title: P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina.
    5. PI3K/P-Rex/Rac pathway is required for late phase long-term potentiation in the mouse cerebellum
      Title: Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    6. P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function
      Title: P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
    Names
    DEP domain containing 2
    DEP domain-containing protein 2
    ptdIns(3,4,5)-dependent Rac exchanger 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033636.4 → NP_001028808.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 2

      See identical proteins and their annotated locations for NP_001028808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR and lacks much of the 5' coding region when compared to variant 1. The resulting protein (isoform 2) is much shorter when it is compared to isoform 1.
      Source sequence(s)
      AC164600, AI553603, AK136059
      UniProtKB/TrEMBL
      Q3UWW3

    2. NM_029525.1 → NP_083801.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 1

      See identical proteins and their annotated locations for NP_083801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC102481, AC102631, AC164600, AI553603, AK138884
      Consensus CDS
      CCDS48217.1
      UniProtKB/Swiss-Prot
      E9QMG3, Q3LAC4, Q3UQI2, Q3UU18, Q9CXD5
      Related
      ENSMUSP00000027056.6, ENSMUST00000027056.12
      Conserved Domains (6) summary
      cd00992
      Location:669 → 736
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04439
      Location:374 → 454
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:466 → 558
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:210 → 356
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00621
      Location:19 → 204
      RhoGEF; RhoGEF domain
      pfam17820
      Location:607 → 660
      PDZ_6; PDZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      11063496..11373907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495441.5 → XP_006495504.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X1

      Conserved Domains (5) summary
      cd00992
      Location:669 → 736
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04439
      Location:374 → 454
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:466 → 558
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:210 → 356
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00621
      Location:19 → 204
      RhoGEF; RhoGEF domain

    2. XM_036153084.1 → XP_036008977.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X3

      Conserved Domains (6) summary
      cd00992
      Location:669 → 736
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04439
      Location:374 → 454
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:466 → 558
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:210 → 356
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00621
      Location:19 → 204
      RhoGEF; RhoGEF domain
      pfam17820
      Location:607 → 660
      PDZ_6; PDZ domain

    3. XM_036153075.1 → XP_036008968.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X2

      Conserved Domains (5) summary
      cd00992
      Location:480 → 547
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04439
      Location:185 → 265
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:277 → 369
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:21 → 167
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam17820
      Location:418 → 471
      PDZ_6; PDZ domain

    RNA

    1. XR_004934097.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3LAC4.2 GenPept UniProtKB/Swiss-Prot:Q3LAC4

    Gene LinkOut

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