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    Mex3b mex3 RNA binding family member B [ Mus musculus (house mouse) ]

    Gene ID: 108797, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mex3bprovided by MGI
    Official Full Name
    mex3 RNA binding family member Bprovided by MGI
    Primary source
    MGI:MGI:1918252
    See related
    Ensembl:ENSMUSG00000057706 AllianceGenome:MGI:1918252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rkhd3; M-04814; mKIAA2009; 4931439A04Rik
    Summary
    Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including positive regulation of GTPase activity; positive regulation of phagocytosis; and protein localization to cell cortex. Predicted to be located in P-body; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cartilage; cranium; and reproductive system. Orthologous to human MEX3B (mex-3 RNA binding family member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 55.4), CNS E14 (RPKM 46.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D3; 7 47.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (82516541..82520784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (82867333..82871576)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29796 Neighboring gene STARR-seq mESC enhancer starr_19392 Neighboring gene predicted gene, 36584 Neighboring gene RIKEN cDNA 1700010L04 gene Neighboring gene STARR-seq mESC enhancer starr_19393 Neighboring gene STARR-positive B cell enhancer ABC_E10448 Neighboring gene RIKEN cDNA 4933430H16 gene Neighboring gene STARR-seq mESC enhancer starr_19395 Neighboring gene predicted gene, 45992 Neighboring gene STARR-seq mESC enhancer starr_19396 Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RNA-binding protein Mex-3B plays critical roles in the development of steroid-resistant neutrophilic airway inflammation. Yamazumi Y, et al. Biochem Biophys Res Commun, 2019 Nov 5. PMID 31493864
    2. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Yang Y, et al. Cell Res, 2016 Mar. PMID 26823206, Free PMC Article
    3. The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation. Yamazumi Y, et al. Cell Rep, 2016 Aug 30. PMID 27545879
    4. Use of intercross outbred mice and single nucleotide polymorphisms to map skin cancer modifier loci. Peissel B, et al. Mamm Genome, 2001 Apr. PMID 11309660
    5. The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway. Le Borgne M, et al. Development, 2014 May. PMID 24803656

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mex-3B facilitates the development of allergic airway inflammation by directly upregulating IL-33 expression via inhibiting miR-487b-3p mediated repression of IL-33.
      Title: The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation.
    2. A study in Mex3b(-/-) mice suggest that Mex3B acts as a coreceptor of TLR3 in innate antiviral response.
      Title: The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.
    3. Mex3b is involved in the spatial organization of the Rap1 pathway that orchestrates Sertoli cell functions.
      Title: The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein MEX3B
    Names
    RING finger and KH domain-containing protein 3
    mex3 homolog B
    ring finger and KH domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175366.3 → NP_780575.2  RNA-binding protein MEX3B

      Status: VALIDATED

      Source sequence(s)
      AC122736
      Consensus CDS
      CCDS52286.1
      UniProtKB/Swiss-Prot
      Q2VPR1, Q69Z36, Q6NX84, Q8K2G2
      UniProtKB/TrEMBL
      F8WJD6
      Related
      ENSMUSP00000082168.5, ENSMUST00000082237.7
      Conserved Domains (3) summary
      smart00322
      Location:167 → 232
      KH; K homology RNA-binding domain
      cd00105
      Location:74 → 134
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd16721
      Location:523 → 565
      RING-HC_MEX3B; RING finger, HC subclass, found in RNA-binding protein MEX3B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      82516541..82520784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69Z36.2 GenPept UniProtKB/Swiss-Prot:Q69Z36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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