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    Ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase [ Mus musculus (house mouse) ]

    Gene ID: 75678, updated on 9-May-2024

    Summary

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    Official Symbol
    Ippkprovided by MGI
    Official Full Name
    inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by MGI
    Primary source
    MGI:MGI:1922928
    See related
    Ensembl:ENSMUSG00000021385 AllianceGenome:MGI:1922928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    InsP6; 1810043M15Rik
    Summary
    Predicted to enable inositol pentakisphosphate 2-kinase activity and molecular adaptor activity. Predicted to be involved in inositol phosphate biosynthetic process; inositol phosphorylation; and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.4), testis adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ippk in Genome Data Viewer
    Location:
    13 A5; 13 25.25 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49574673..49618050)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49421198..49464574)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49363145-49363298 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402581-49402764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402849-49403036 Neighboring gene STARR-positive B cell enhancer ABC_E4067 Neighboring gene BICD cargo adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_34478 Neighboring gene centromere protein P Neighboring gene testis derived transcript 3, pseudogene Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function. Franco-Echevarría E, et al. J Biol Chem, 2017 Jun 23. PMID 28450399, Free PMC Article
    2. Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase. Franco-Echevarría E, et al. Protein J, 2017 Aug. PMID 28429156
    3. Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression. Verbsky J, et al. Proc Natl Acad Sci U S A, 2005 Jun 14. PMID 15939868, Free PMC Article
    4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystallization and preliminary x-ray diffraction analysis of a mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase has been reported.
      Title: Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase.
    2. findings have uncovered distinct features of a mammalian IP5 2-K and set the stage for investigations into protein-protein or protein-RNA interactions important for IP5 2-K function and activity
      Title: The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol pentakisphosphate 2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol pentakisphosphate 2-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inositol-pentakisphosphate 2-kinase
    Names
    ins(1,3,4,5,6)P5 2-kinase
    insP5 2-kinase
    NP_001263328.1
    NP_951011.1
    XP_017171117.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276399.2 → NP_001263328.1  inositol-pentakisphosphate 2-kinase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC123954
      Consensus CDS
      CCDS88452.1
      UniProtKB/TrEMBL
      A0A217FL54
      Related
      ENSMUSP00000021817.10, ENSMUST00000021817.10
      Conserved Domains (1) summary
      pfam06090
      Location:80 → 504
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    2. NM_199056.4 → NP_951011.1  inositol-pentakisphosphate 2-kinase isoform a

      See identical proteins and their annotated locations for NP_951011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AC123954
      Consensus CDS
      CCDS26500.1
      UniProtKB/Swiss-Prot
      Q3V3Z0, Q6P1C1
      UniProtKB/TrEMBL
      Q05CK0
      Related
      ENSMUSP00000152331.2, ENSMUST00000220447.2
      Conserved Domains (1) summary
      pfam06090
      Location:13 → 455
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    RNA

    1. NR_075085.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123954, AK160092, AV306360, BB619387, CD353694, DV647168
      Related
      ENSMUST00000220856.2

    2. NR_165080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123954

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49574673..49618050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315628.3 → XP_017171117.1  inositol-pentakisphosphate 2-kinase isoform X1

      Conserved Domains (1) summary
      pfam06090
      Location:13 → 201
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1C1.1 GenPept UniProtKB/Swiss-Prot:Q6P1C1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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