Map3k10 mitogen-activated protein kinase kinase kinase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map3k10provided by MGI
Official Full Name: mitogen-activated protein kinase kinase kinase 10provided by MGI
Primary source: MGI:MGI:1346879
See related: Ensembl:ENSMUSG00000040390 AllianceGenome:MGI:1346879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MST; Mlk2
Summary: Enables protein kinase activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription, DNA-templated and protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in brown fat; heart; ovary; renal vasculature; and testis. Orthologous to human MAP3K10 (mitogen-activated protein kinase kinase kinase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 23.3), frontal lobe adult (RPKM 19.8) and 25 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 A3; 7 15.95 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27355800..27374059, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (27656375..27674630, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways
Title: Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.
There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse.
Title: Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IPI Inferred from Physical Interaction more info	PubMed
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: mitogen-activated protein kinase kinase kinase 10

Names: MKN28 derived nonreceptor_type; MKN28 kinase; mixed lineage kinase 2; serine/threonine kinase

NP_001277457.1

EC 2.7.11.25

XP_017177776.1

EC 2.7.11.25

XP_017177777.1

EC 2.7.11.25

XP_017177778.1

EC 2.7.11.25

XP_017177779.1

EC 2.7.11.25

XP_030098477.1

EC 2.7.11.25

XP_030098478.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290528.1 → NP_001277457.1 mitogen-activated protein kinase kinase kinase 10

See identical proteins and their annotated locations for NP_001277457.1

Status: VALIDATED

Source sequence(s)

AK053830, BC078445

Consensus CDS

CCDS39850.2

UniProtKB/Swiss-Prot

Q66L42, Q80UW4

UniProtKB/TrEMBL

D3YXM8

Related

ENSMUSP00000037725.8, ENSMUST00000036453.14

Conserved Domains (3) summary

smart00219
Location:98 → 357

TyrKc; Tyrosine kinase, catalytic domain

cd12059
Location:20 → 76

SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3

cl21453
Location:103 → 360

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

27355800..27374059 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322288.3 → XP_017177777.1 mitogen-activated protein kinase kinase kinase 10 isoform X2

UniProtKB/TrEMBL

D3YXM8

Conserved Domains (2) summary

cd12059
Location:20 → 76

SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3

cl21453
Location:103 → 360

PKc_like; Protein Kinases, catalytic domain
XM_017322289.3 → XP_017177778.1 mitogen-activated protein kinase kinase kinase 10 isoform X3

UniProtKB/TrEMBL

D3YXM8

Conserved Domains (2) summary

cd12059
Location:20 → 76

SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3

cl21453
Location:103 → 368

PKc_like; Protein Kinases, catalytic domain
XM_017322287.3 → XP_017177776.1 mitogen-activated protein kinase kinase kinase 10 isoform X1

UniProtKB/TrEMBL

D3YXM8

Conserved Domains (2) summary

cd12059
Location:20 → 76

SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3

cl21453
Location:103 → 368

PKc_like; Protein Kinases, catalytic domain
XM_030242618.2 → XP_030098478.1 mitogen-activated protein kinase kinase kinase 10 isoform X6

Conserved Domains (2) summary

TIGR03319
Location:4 → 88

RNase_Y; ribonuclease Y

PHA03247
Location:252 → 550

PHA03247; large tegument protein UL36; Provisional
XM_030242617.2 → XP_030098477.1 mitogen-activated protein kinase kinase kinase 10 isoform X5

Conserved Domains (2) summary

PHA03247
Location:295 → 593

PHA03247; large tegument protein UL36; Provisional

pfam12072
Location:72 → 132

DUF3552; Domain of unknown function (DUF3552)
XM_017322290.3 → XP_017177779.1 mitogen-activated protein kinase kinase kinase 10 isoform X4

Conserved Domains (3) summary

PHA03247
Location:410 → 708

PHA03247; large tegument protein UL36; Provisional

pfam12072
Location:187 → 247

DUF3552; Domain of unknown function (DUF3552)

cl21453
Location:1 → 108

PKc_like; Protein Kinases, catalytic domain

RNA

XR_004934110.1 RNA Sequence
XR_004934109.1 RNA Sequence
XR_001785564.3 RNA Sequence
XR_004934112.1 RNA Sequence
XR_004934111.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081292.1: Suppressed sequence

Description

NM_001081292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.