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    Eldr Egfr long non-coding downstream RNA [ Mus musculus (house mouse) ]

    Gene ID: 72735, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Eldrprovided by MGI
    Official Full Name
    Egfr long non-coding downstream RNAprovided by MGI
    Primary source
    MGI:MGI:1919985
    See related
    Ensembl:ENSMUSG00000087060 AllianceGenome:MGI:1919985
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fabl; 2810442I21Rik; 4930500E12Rik
    Summary
    Acts upstream of or within regulation of gene expression and response to wounding. Is expressed in brain; cortical layer VI; neocortex; telencephalon mantle layer; and telencephalon ventricular layer. Orthologous to human ELDR (EGFR long non-coding downstream RNA). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 3.2), limb E14.5 (RPKM 2.1) and 12 other tissues See more
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    Genomic context

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    Location:
    11 A2; 11 9.41 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16884709..16901282, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16934709..16951282, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor Neighboring gene predicted gene, 39584 Neighboring gene STARR-seq mESC enhancer starr_28696 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene F-box protein 48 Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene pleckstrin Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene signal peptide, CUB domain, EGF-like 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emerging role of lncRNA ELDR in development and cancer. Sur S, et al. FEBS J, 2022 Jun. PMID 33860640
    2. Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis. Ji ML, et al. Am J Hum Genet, 2023 Apr 6. PMID 36868238, Free PMC Article
    3. Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain. Goff LA, et al. Proc Natl Acad Sci U S A, 2015 Jun 2. PMID 26034286, Free PMC Article
    4. Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs. Lai KM, et al. PLoS One, 2015. PMID 25909911, Free PMC Article
    5. Identification of candidate long non-coding RNAs in response to myocardial infarction. Zangrando J, et al. BMC Genomics, 2014 Jun 10. PMID 24917243, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis.
      Title: Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis.
    2. Emerging role of lncRNA ELDR in development and cancer.
      Title: Emerging role of lncRNA ELDR in development and cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110421.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK015657, AL645532, BI990615

    2. NR_110422.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon and uses an alternate splice site at the 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AK015657, AL645532

    3. NR_110423.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal exons and uses an alternate splice site at the 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL645532

    4. NR_110424.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate internal exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AK013290, AK015657, AL645532, BI990615
      Related
      ENSMUST00000123734.9

    5. NR_110425.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate internal exons and uses an alternate splice site at the 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AK013290, AK015657, AL645532

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      16884709..16901282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015469.1: Suppressed sequence

      Description
      NR_015469.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases