Ep400 E1A binding protein p400 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ep400provided by MGI
Official Full Name: E1A binding protein p400provided by MGI
Primary source: MGI:MGI:1276124
See related: Ensembl:ENSMUSG00000029505 AllianceGenome:MGI:1276124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p400; mDomino; mKIAA1498; 1700020J09Rik
Summary: Predicted to enable chromatin binding activity and protein antigen binding activity. Predicted to be involved in histone H2A acetylation and histone H4 acetylation. Predicted to act upstream of or within chromatin organization. Located in nuclear speck. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut; and trachea. Orthologous to human EP400 (E1A binding protein p400). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 36.8), thymus adult (RPKM 23.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.69 cM

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (110812239..110918583, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (110664373..110770927, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Global identification of SWI/SNF targets reveals compensation by EP400.
Title: Global identification of SWI/SNF targets reveals compensation by EP400.
The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development.
Title: The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development.
Whereas Ep400-deficient oligodendrocyte precursors develop normally, terminal differentiation and myelination are dramatically impaired.
Title: Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system.
Ep400 absence causes peripheral neuropathy in mice, characterized by terminal differentiation defects in myelinating and non-myelinating Schwann cells and immune cell activation.
Title: Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.
incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation
Title: The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.
p400/mDomino plays a key role in cellular proliferation by controlling the expression of cell-cycle-regulatory genes.
Title: Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression.
These data indicate that Tip60-p400 integrates signals from Nanog and H3K4me3 to regulate gene expression in embryonic stem cells.
Title: An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.
senescence induced by VHL inactivation is a tumour-suppressive mechanism mediated by Rb and p400 (and HIF independent) that must be overcome to develop VHL-associated neoplasias
Title: VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
p400 is a regulator of the ARF-p53 pathway and a component of the cellular machinery that couples proliferation to cell death
Title: p400 is required for E1A to promote apoptosis.
p400/mDomino plays a critical role in embryonic hematopoiesis by regulating the expression of developmentally essential genes such as those in the Hox gene cluster.
Title: Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Swr1 complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E1A-binding protein p400

Names: domino homolog; p400 kDa SWI2/SNF2-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029337.2 → NP_083613.2 E1A-binding protein p400 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.

Source sequence(s)

AC161348

Consensus CDS

CCDS19529.1

UniProtKB/Swiss-Prot

E9QKV1, Q3TPY1, Q5RKN8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8CHI8, Q8VDF4, Q9DA54

Related

ENSMUSP00000049038.9, ENSMUST00000041558.15

Conserved Domains (7) summary

PHA03255
Location:2511 → 2639

PHA03255; BDLF3; Provisional

smart00573
Location:762 → 833

HSA; domain in helicases and associated with SANT domains

cd00046
Location:1073 → 1208

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:1056 → 1336

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1776 → 1892

Helicase_C; Helicase conserved C-terminal domain

pfam03153
Location:2822 → 3011

TFIIA; Transcription factor IIA, alpha/beta subunit

pfam15790
Location:1 → 451

EP400_N; E1A-binding protein p400, N-terminal
NM_173066.1 → NP_775089.1 E1A-binding protein p400 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2), also called mDomino-S, lacks an in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC161348

Consensus CDS

CCDS51612.1

UniProtKB/Swiss-Prot

E9QKV1, Q3TPY1, Q5RKN8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8CHI8, Q8VDF4, Q9DA54

Related

ENSMUSP00000108055.3, ENSMUST00000112436.9

Conserved Domains (7) summary

PHA03255
Location:2475 → 2603

PHA03255; BDLF3; Provisional

smart00573
Location:726 → 797

HSA; domain in helicases and associated with SANT domains

cd00046
Location:1037 → 1172

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:1020 → 1300

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1740 → 1856

Helicase_C; Helicase conserved C-terminal domain

pfam03153
Location:2786 → 2975

TFIIA; Transcription factor IIA, alpha/beta subunit

pfam15790
Location:1 → 451

EP400_N; E1A-binding protein p400, N-terminal