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    Kcnq5 potassium voltage-gated channel, subfamily Q, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 226922, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kcnq5provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily Q, member 5provided by MGI
    Primary source
    MGI:MGI:1924937
    See related
    Ensembl:ENSMUSG00000028033 AllianceGenome:MGI:1924937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Mgi1; 7730402H11; 9230107O05Rik
    Summary
    Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be integral component of plasma membrane. Predicted to be part of clathrin coat and voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 3.9), frontal lobe adult (RPKM 3.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 A4; 1 6.67 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21468623..22032874, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21398399..21962650, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:21459459-21459687 Neighboring gene predicted gene, 33147 Neighboring gene KH domain containing 1 pseudogene Neighboring gene KH domain containing 1B Neighboring gene STARR-seq mESC enhancer starr_00409 Neighboring gene STARR-seq mESC enhancer starr_00410 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene STARR-seq mESC enhancer starr_00411 Neighboring gene STARR-seq mESC enhancer starr_00412 Neighboring gene predicted gene, 53539 Neighboring gene STARR-seq mESC enhancer starr_00414 Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00415 Neighboring gene STARR-seq mESC enhancer starr_00416 Neighboring gene STARR-seq mESC enhancer starr_00417 Neighboring gene regulating synaptic membrane exocytosis 1 Neighboring gene STARR-seq mESC enhancer starr_00419 Neighboring gene STARR-seq mESC enhancer starr_00422

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. Tzingounis AV, et al. Proc Natl Acad Sci U S A, 2010 Jun 1. PMID 20534576, Free PMC Article
    2. KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3. Soh H, et al. Proc Natl Acad Sci U S A, 2022 Mar 29. PMID 35320039, Free PMC Article
    3. KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations. Fidzinski P, et al. Nat Commun, 2015 Feb 4. PMID 25649132
    4. Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models. Spitzmaul G, et al. J Biol Chem, 2013 Mar 29. PMID 23408425, Free PMC Article
    5. Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles. Jepps TA, et al. Am J Physiol Gastrointest Liver Physiol, 2009 Jul. PMID 19389803, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation.
      Title: KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation.
    2. KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
      Title: KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
    3. KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition.
      Title: KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
    4. analysis of the vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models
      Title: Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
    5. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 > KCNQ5 > KCNQ1 > KCNQ2.
      Title: The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
    6. Kcnq5(dn/dn) mice are viable and have normal brain morphology. However, in the CA3 area of hippocampus, a region that highly expresses KCNQ5 channels, the medium and slow afterhyperpolarization currents are significantly reduced.
      Title: The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
    7. K(v)7.4 and K(v)7.5 are expressed in different regions of the murine gastrointestinal tract and blockers of K(v)7 channels augment inherent contractile activity.
      Title: Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
    8. Results provide support for KCNQ4- or KCNQ5-encoded channels having an important functional impact in the vasculature.
      Title: Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
    9. These data represent an exhaustive characterisation of a truncated KCNQ5 splice variant that may contribute to the native XE991-sensitive channel in murine vasculature.
      Title: Expression profile and characterisation of a truncated KCNQ5 splice variant.
    10. Murine blood vessels exhibit a distinctive expression profile of KCNQ1, KCNQ4, and KCNQ5, with 'neuronal' KCNQ4 dominating
      Title: Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily KQT member 5
    Names
    KQT-like 5
    potassium channel subunit alpha KvLQT5
    voltage-gated potassium channel subunit Kv7.5
    voltage-gated potassium channel type Kv7.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160139.1 → NP_001153611.1  potassium voltage-gated channel subfamily KQT member 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AK147264, AW493240, BE648243, CX239866
      Consensus CDS
      CCDS48230.1
      UniProtKB/TrEMBL
      E9Q9F1, G3UYP4
      Related
      ENSMUSP00000110955.2, ENSMUST00000115300.8
      Conserved Domains (3) summary
      pfam00520
      Location:161 → 359
      Ion_trans; Ion transport protein
      pfam03520
      Location:473 → 660
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:275 → 349
      Ion_trans_2; Ion channel

    2. NM_001310477.1 → NP_001297406.1  potassium voltage-gated channel subfamily KQT member 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) omits two in-frame coding exons, compared to variant 1, resulting in a shorter protein (isoform 3).
      Source sequence(s)
      AC115920, AC125483, AC131088
      Consensus CDS
      CCDS78554.1
      UniProtKB/TrEMBL
      G3UYG5, G3UYP4
      Related
      ENSMUSP00000134076.2, ENSMUST00000173404.2
      Conserved Domains (3) summary
      pfam00520
      Location:161 → 359
      Ion_trans; Ion transport protein
      pfam03520
      Location:445 → 632
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:275 → 349
      Ion_trans_2; Ion channel

    3. NM_023872.3 → NP_076361.1  potassium voltage-gated channel subfamily KQT member 5 isoform 2

      See identical proteins and their annotated locations for NP_076361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) omits an in-frame coding exon, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AK147264, AW493240, AY679158, BE648243, CX239866
      Consensus CDS
      CCDS35525.1
      UniProtKB/Swiss-Prot
      Q4QXS5, Q8BSF6, Q9JK45
      UniProtKB/TrEMBL
      G3UYP4
      Related
      ENSMUSP00000029667.7, ENSMUST00000029667.13
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 359
      Ion_trans; Ion transport protein
      pfam03520
      Location:448 → 635
      KCNQ_channel; KCNQ voltage-gated potassium channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      21468623..22032874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164276.1 → XP_036020169.1  potassium voltage-gated channel subfamily KQT member 5 isoform X1

      UniProtKB/TrEMBL
      G3UYP4
      Conserved Domains (2) summary
      pfam00520
      Location:5 → 229
      Ion_trans; Ion transport protein
      pfam03520
      Location:337 → 524
      KCNQ_channel; KCNQ voltage-gated potassium channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JK45.2 GenPept UniProtKB/Swiss-Prot:Q9JK45

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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