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    Arpc5l actin related protein 2/3 complex, subunit 5-like [ Mus musculus (house mouse) ]

    Gene ID: 74192, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Arpc5lprovided by MGI
    Official Full Name
    actin related protein 2/3 complex, subunit 5-likeprovided by MGI
    Primary source
    MGI:MGI:1921442
    See related
    Ensembl:ENSMUSG00000026755 AllianceGenome:MGI:1921442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARC16-2; 2010015J01Rik
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in glutamatergic synapse. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and integumental system. Orthologous to human ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 20.9), testis adult (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 24.42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38895283..38905889)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39008066..39015878)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 29985 Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene golgin A1 Neighboring gene predicted gene, 26127 Neighboring gene STARR-positive B cell enhancer ABC_E9512 Neighboring gene suppressor of cancer cell invasion Neighboring gene predicted gene, 30067 Neighboring gene STARR-seq mESC enhancer starr_04343

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Olthof AM, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33660780, Free PMC Article
    2. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
    3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
    4. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin-related protein 2/3 complex subunit 5-like protein
    Names
    arp2/3 complex 16 kDa subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418772.1 → NP_001405701.1  actin-related protein 2/3 complex subunit 5-like protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AL844588

    2. NM_001418773.1 → NP_001405702.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AL844588

    3. NM_001418775.1 → NP_001405704.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AL844588

    4. NM_001418776.1 → NP_001405705.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AL844588

    5. NM_001418778.1 → NP_001405707.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AL844588

    6. NM_028809.2 → NP_083085.1  actin-related protein 2/3 complex subunit 5-like protein isoform a

      See identical proteins and their annotated locations for NP_083085.1

      Status: VALIDATED

      Source sequence(s)
      AL844588
      Consensus CDS
      CCDS38120.1
      UniProtKB/Swiss-Prot
      Q9D898
      Related
      ENSMUSP00000108483.3, ENSMUST00000112862.7
      Conserved Domains (1) summary
      pfam04699
      Location:9 → 151
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      38895283..38905889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D898.1 GenPept UniProtKB/Swiss-Prot:Q9D898

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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