Dpysl5 dihydropyrimidinase-like 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpysl5provided by MGI
Official Full Name: dihydropyrimidinase-like 5provided by MGI
Primary source: MGI:MGI:1929772
See related: Ensembl:ENSMUSG00000029168 AllianceGenome:MGI:1929772
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRAM; Crmp5; CRMP-5
Summary: Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and microtubule binding activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within axon guidance. Located in cytoplasm; dendrite; and neuronal cell body. Is expressed in brain; cerebral cortex marginal layer; cerebral cortex marginal zone; and cortical plate. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome. Orthologous to human DPYSL5 (dihydropyrimidinase like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 113.7), whole brain E14.5 (RPKM 105.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 16.8 cM; 5 B1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (30868908..30956713)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (30711564..30799369)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRMP5 participates in oocyte meiosis by regulating spastin to correct microtubule-kinetochore misconnection.
Title: CRMP5 participates in oocyte meiosis by regulating spastin to correct microtubule-kinetochore misconnection.
Spastin interacts with CRMP5 to promote spindle organization in mouse oocytes by severing microtubules.
Title: Spastin interacts with CRMP5 to promote spindle organization in mouse oocytes by severing microtubules.
Collapsin response mediator protein 5 (CRMP5) modulates susceptibility to chronic social defeat stress in mice.
Title: Collapsin response mediator protein 5 (CRMP5) modulates susceptibility to chronic social defeat stress in mice.
results suggest that CRMP5 regulates social behavior via modulation of surface GluA2 trafficking and affects memory performance in Alzheimer Disease mice.
Title: Collapsin response mediator protein 5 (CRMP5) causes social deficits and accelerates memory loss in an animal model of Alzheimer's disease.
Data show that SRY-box containing gene 5 protein (Sox5) can physically bind to the collapsin response mediator protein 5 (CRMP5) promoter DNA.
Title: Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.
study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function.
Title: Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.
CRMP5-deficient mice show abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons.
Title: The collapsin response mediator protein 5 onconeural protein is expressed in Schwann cells under axonal signals and regulates axon-Schwann cell interactions.
These findings provide the first evidence that CRMP5 is involved in the generation and survival of newly generated neurons in areas of the adult brain with a high level of activity-dependent neuronal plasticity.
Title: CRMP5 regulates generation and survival of newborn neurons in olfactory and hippocampal neurogenic areas of the adult mouse brain.
Data show that CRMP5 is involved in the development, maintenance and synaptic plasticity of Purkinje cells.
Title: CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.
The CRMP5 binding to tubulin modulates CRMP2 regulation of neurite outgrowth and neuronal polarity during brain development.
Title: CRMP5 interacts with tubulin to inhibit neurite outgrowth, thereby modulating the function of CRMP2.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

IB426 (e-PCR)
- UniSTS:12852

D5Jcs303 (e-PCR), detects polymorphism
- UniSTS:479312

UniSTS:478904 (e-PCR)
- UniSTS:478904

D5Jcs68 (e-PCR), detects polymorphism
- UniSTS:478904

D5Jcs69 (e-PCR), detects polymorphism
- UniSTS:478905

D5Jcs70 (e-PCR), detects polymorphism
- UniSTS:478906

RH131974 (e-PCR)
- UniSTS:215257

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: dihydropyrimidinase-related protein 5

Names: DRP-5; collapsin response mediator protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356948.1 → NP_001343877.1 dihydropyrimidinase-related protein 5 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC105298, AC109611

Consensus CDS

CCDS39047.1

UniProtKB/Swiss-Prot

Q9EQF6

Related

ENSMUSP00000110377.2, ENSMUST00000114729.8

Conserved Domains (1) summary

cd01314
Location:10 → 459

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
NM_001356949.1 → NP_001343878.1 dihydropyrimidinase-related protein 5 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC105298, BC103789

Consensus CDS

CCDS89896.1

UniProtKB/TrEMBL

Q3SYJ1

Related

ENSMUSP00000098985.4, ENSMUST00000101442.4

Conserved Domains (1) summary

cl00281
Location:10 → 87

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
NM_023047.3 → NP_075534.1 dihydropyrimidinase-related protein 5 isoform a

See identical proteins and their annotated locations for NP_075534.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC105298, BC065054

Consensus CDS

CCDS39047.1

UniProtKB/Swiss-Prot

Q9EQF6

Related

ENSMUSP00000085400.5, ENSMUST00000088081.11

Conserved Domains (1) summary

cd01314
Location:10 → 459

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...