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    Plcb4 phospholipase C, beta 4 [ Mus musculus (house mouse) ]

    Gene ID: 18798, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Plcb4provided by MGI
    Official Full Name
    phospholipase C, beta 4provided by MGI
    Primary source
    MGI:MGI:107464
    See related
    Ensembl:ENSMUSG00000039943 AllianceGenome:MGI:107464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930039J07Rik; C230058B11Rik
    Summary
    Predicted to enable mitogen-activated protein kinase binding activity and phosphatidylinositol phospholipase C activity. Involved in modulation of chemical synaptic transmission. Located in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and smooth endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 32.1), cerebellum adult (RPKM 16.4) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F3; 2 66.64 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (135500523..135856522)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (135658603..136014602)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630028H03 gene Neighboring gene STARR-seq mESC enhancer starr_05784 Neighboring gene pluripotency associated transcript 3 Neighboring gene STARR-seq mESC enhancer starr_05788 Neighboring gene predicted gene, 54134 Neighboring gene STARR-seq mESC enhancer starr_05793 Neighboring gene predicted gene 14210 Neighboring gene STARR-seq mESC enhancer starr_05794 Neighboring gene STARR-seq mESC enhancer starr_05795 Neighboring gene predicted gene, 54133 Neighboring gene predicted gene, 26227 Neighboring gene lysosomal-associated membrane protein family, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation. Hong J, et al. Sci Rep, 2020 Jun 1. PMID 32483199, Free PMC Article
    2. Neural circuits underlying a psychotherapeutic regimen for fear disorders. Baek J, et al. Nature, 2019 Feb. PMID 30760920
    3. Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice. Lee S, et al. Nat Neurosci, 2011 Dec 25. PMID 22197828
    4. Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors. Shin J, et al. J Neurosci, 2009 Dec 9. PMID 20007462, Free PMC Article
    5. Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures. Cheong E, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 19955421, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SENP2-PLCbeta4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
      Title: SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
    2. Destabilization of light NREM sleep by thalamic PLCbeta4 deletion impairs sleep-dependent memory consolidation.
      Title: Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation.
    3. Thrombosis suppression by heterozygous Plcb4 loss of function was confirmed through analysis of an independent, CRISPR/Cas9-induced Plcb4 mutation in transgenic mice.
      Title: Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
    4. The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture.
      Title: The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture.
    5. Tnis study demonistrated that plc beta4 distribuate in mice cerebellum
      Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
    6. Presence of PLCbeta(4) in the heart and in HL-1 cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts.
      Title: Phospholipase Cbeta4 isozyme is expressed in human, rat, and murine heart left ventricles and in HL-1 cardiomyocytes.
    7. impaired LGNd relay, possibly mediated via group-1 mGluR, may underlie irregular sleep sequences and ultradian body temperature rhythms in PLC-beta4-/- mice
      Title: Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice.
    8. deletion of thalamic PLCbeta4 leads to the genesis of absence seizures
      Title: Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures.
    9. These findings suggest that (1) PLC-beta 4 in the medial septum is involved in controlling cholinergic theta oscillation and (2) cholinergic theta rhythm plays a critical role in suppressing anxiety.
      Title: Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors.
    10. In this study identify phospholipase C (PLC) beta4 as an antigenic marker of a novel subset of unipolar brush cells. Double immunolabeling reveals that most members of the mGluR1alpha subset also express PLCbeta4.
      Title: Phospholipase Cbeta4 expression identifies a novel subset of unipolar brush cells in the adult mouse cerebellum.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating endothelin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in smooth endoplasmic reticulum IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
    NP_001342082.1
    NP_001342083.1
    NP_001342084.1
    NP_001342085.1
    NP_038857.1
    XP_006498999.1
    XP_006499000.1
    XP_006499001.1
    XP_006499002.1
    XP_006499004.1
    XP_006499006.1
    XP_006499008.1
    XP_006499009.1
    XP_006499010.1
    XP_006499011.1
    XP_006499013.1
    XP_011237659.1
    XP_011237661.1
    XP_030104392.1
    XP_030104397.1
    XP_030104399.1
    XP_036015472.1
    XP_036015477.1
    XP_036015478.1
    XP_036015483.1
    XP_036015485.1
    XP_036015489.1
    XP_036015500.1
    XP_036015503.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355153.1 → NP_001342082.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL928798, AL929052, AL935301
      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:847 → 1194
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914 → 955
      DUF1154; Protein of unknown function (DUF1154)

    2. NM_001355154.1 → NP_001342083.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate 3' exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AL928798, AL935301
      Consensus CDS
      CCDS16788.1
      UniProtKB/TrEMBL
      Q91UZ1, V9GXQ9
      Related
      ENSMUSP00000038409.5, ENSMUST00000035646.11
      Conserved Domains (6) summary
      PTZ00121
      Location:839 → 1170
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914 → 955
      DUF1154; Protein of unknown function (DUF1154)

    3. NM_001355155.1 → NP_001342084.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate in-frame 5' exon and lacks an alternate 3' exon compared to variant 1, that causes a frameshift. The resulting isoform (c) has an alternate internal segment and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL928798, AL929052, AL935301
      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:851 → 1182
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    4. NM_001355156.1 → NP_001342085.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate 5' exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL928798, AL929052, AL935301
      Conserved Domains (4) summary
      PTZ00121
      Location:579 → 926
      PTZ00121; MAEBL; Provisional
      cd08591
      Location:44 → 400
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:16 → 539
      PLN02228; Phosphoinositide phospholipase C
      pfam06631
      Location:646 → 687
      DUF1154; Protein of unknown function (DUF1154)

    5. NM_013829.3 → NP_038857.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

      See identical proteins and their annotated locations for NP_038857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 3' exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AL928798, AL929052, AL935301
      Consensus CDS
      CCDS16788.1
      UniProtKB/TrEMBL
      Q91UZ1, V9GXQ9
      Related
      ENSMUSP00000105736.2, ENSMUST00000110109.8
      Conserved Domains (6) summary
      PTZ00121
      Location:839 → 1170
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914 → 955
      DUF1154; Protein of unknown function (DUF1154)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      135500523..135856522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239359.4 → XP_011237661.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_011237661.1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:860 → 1207
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    2. XM_036159592.1 → XP_036015485.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:847 → 1194
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914 → 955
      DUF1154; Protein of unknown function (DUF1154)

    3. XM_030248537.2 → XP_030104397.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:848 → 1195
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:703 → 819
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 669
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:915 → 956
      DUF1154; Protein of unknown function (DUF1154)

    4. XM_006498936.4 → XP_006498999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_006498999.1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:860 → 1207
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    5. XM_006498941.2 → XP_006499004.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:852 → 1183
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    6. XM_006498943.3 → XP_006499006.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X6

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:840 → 1171
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:703 → 819
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 669
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:915 → 956
      DUF1154; Protein of unknown function (DUF1154)

    7. XM_011239357.4 → XP_011237659.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_011237659.1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:860 → 1207
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    8. XM_006498939.4 → XP_006499002.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:848 → 1195
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:703 → 819
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 669
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:915 → 956
      DUF1154; Protein of unknown function (DUF1154)

    9. XM_006498938.4 → XP_006499001.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    10. XM_036159579.1 → XP_036015472.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:860 → 1207
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    11. XM_036159584.1 → XP_036015477.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:860 → 1207
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    12. XM_036159610.1 → XP_036015503.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X11

      Conserved Domains (4) summary
      PTZ00121
      Location:591 → 938
      PTZ00121; MAEBL; Provisional
      cd08591
      Location:44 → 412
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:16 → 551
      PLN02228; Phosphoinositide phospholipase C
      pfam06631
      Location:658 → 699
      DUF1154; Protein of unknown function (DUF1154)

    13. XM_036159585.1 → XP_036015478.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:859 → 1206
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:714 → 830
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 680
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:926 → 967
      DUF1154; Protein of unknown function (DUF1154)

    14. XM_036159596.1 → XP_036015489.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:847 → 1194
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914 → 955
      DUF1154; Protein of unknown function (DUF1154)

    15. XM_036159590.1 → XP_036015483.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:848 → 1195
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:703 → 819
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 669
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:915 → 956
      DUF1154; Protein of unknown function (DUF1154)

    16. XM_030248532.2 → XP_030104392.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:860 → 1207
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    17. XM_006498937.5 → XP_006499000.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

      See identical proteins and their annotated locations for XP_006499000.1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:860 → 1207
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:715 → 831
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 681
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:927 → 968
      DUF1154; Protein of unknown function (DUF1154)

    18. XM_030248539.2 → XP_030104399.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:847 → 1194
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:702 → 818
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:312 → 668
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:17 → 143
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16211
      Location:148 → 300
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:914 → 955
      DUF1154; Protein of unknown function (DUF1154)

    19. XM_006498945.5 → XP_006499008.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X7

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (6) summary
      PTZ00121
      Location:747 → 1094
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:602 → 718
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:199 → 568
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd16211
      Location:35 → 187
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:814 → 855
      DUF1154; Protein of unknown function (DUF1154)
      cl17171
      Location:1 → 30
      PH-like; Pleckstrin homology-like domain

    20. XM_036159607.1 → XP_036015500.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X10

      Conserved Domains (4) summary
      PTZ00121
      Location:592 → 939
      PTZ00121; MAEBL; Provisional
      cd08591
      Location:44 → 413
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:16 → 552
      PLN02228; Phosphoinositide phospholipase C
      pfam06631
      Location:659 → 700
      DUF1154; Protein of unknown function (DUF1154)

    21. XM_006498947.5 → XP_006499010.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8

      See identical proteins and their annotated locations for XP_006499010.1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (5) summary
      PTZ00121
      Location:717 → 1064
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:572 → 688
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:169 → 538
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd16211
      Location:5 → 157
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:784 → 825
      DUF1154; Protein of unknown function (DUF1154)

    22. XM_006498946.5 → XP_006499009.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X8

      See identical proteins and their annotated locations for XP_006499009.1

      UniProtKB/TrEMBL
      V9GXQ9
      Conserved Domains (5) summary
      PTZ00121
      Location:717 → 1064
      PTZ00121; MAEBL; Provisional
      cd00275
      Location:572 → 688
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:169 → 538
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd16211
      Location:5 → 157
      EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
      pfam06631
      Location:784 → 825
      DUF1154; Protein of unknown function (DUF1154)

    23. XM_006498948.5 → XP_006499011.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X12

      Conserved Domains (6) summary
      PTZ00121
      Location:693 → 1040
      PTZ00121; MAEBL; Provisional
      cd08591
      Location:145 → 514
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:117 → 653
      PLN02228; Phosphoinositide phospholipase C
      cd15898
      Location:100 → 133
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:82 → 133
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      pfam06631
      Location:760 → 801
      DUF1154; Protein of unknown function (DUF1154)

    24. XM_006498950.4 → XP_006499013.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X9

      Conserved Domains (6) summary
      PTZ00121
      Location:613 → 960
      PTZ00121; MAEBL; Provisional
      cd08591
      Location:65 → 434
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02228
      Location:37 → 573
      PLN02228; Phosphoinositide phospholipase C
      cd15898
      Location:20 → 53
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:2 → 53
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      pfam06631
      Location:680 → 721
      DUF1154; Protein of unknown function (DUF1154)
    Nucleotide Protein Strain
    Heading Accession and Version

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