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    Fermt3 fermitin family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 108101, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fermt3provided by MGI
    Official Full Name
    fermitin family member 3provided by MGI
    Primary source
    MGI:MGI:2147790
    See related
    Ensembl:ENSMUSG00000024965 AllianceGenome:MGI:2147790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kindlin3
    Summary
    Enables integrin binding activity. Involved in several processes, including integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by integrin. Located in podosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and lung. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 110.9), spleen adult (RPKM 102.1) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 5.13 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6976326..6996837, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6998958..7019469, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1971 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052 Neighboring gene STARR-seq mESC enhancer starr_45447 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_45448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7140992-7141179 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene fibronectin leucine rich transmembrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones. Klapproth S, et al. J Cell Sci, 2021 Nov 15. PMID 34704600
    2. Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain. Ni T, et al. Biochem J, 2017 Feb 15. PMID 27974389, Free PMC Article
    3. Interaction of kindlin-3 and β2-integrins differentially regulates neutrophil recruitment and NET release in mice. Xu Z, et al. Blood, 2015 Jul 16. PMID 26056166
    4. Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Moretti FA, et al. Proc Natl Acad Sci U S A, 2013 Oct 15. PMID 24089451, Free PMC Article
    5. The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis. Cohen SJ, et al. Blood, 2013 Oct 10. PMID 23980064

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
      Title: Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
    2. Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
      Title: Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
    3. Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.
      Title: Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.
    4. Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
      Title: Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
    5. Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
      Title: Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3.
    6. Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.
      Title: Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.
    7. Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches.
      Title: Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches.
    8. Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance.
      Title: Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance.
    9. Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice.
      Title: Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice.
    10. The kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling.
      Title: A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36836, MGC38286

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell-cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell-substrate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fermitin family homolog 3
    Names
    unc-112-related protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362399.1 → NP_001349328.1  fermitin family homolog 3

      Status: VALIDATED

      Source sequence(s)
      AC120557, AC163098
      Consensus CDS
      CCDS29518.1
      UniProtKB/Swiss-Prot
      Q8K1B8
      UniProtKB/TrEMBL
      Q3TEE6
      Conserved Domains (4) summary
      smart00295
      Location:221 → 301
      B41; Band 4.1 homologues
      cd01237
      Location:350 → 474
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:550 → 641
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      pfam00373
      Location:490 → 555
      FERM_M; FERM central domain

    2. NM_153795.2 → NP_722490.1  fermitin family homolog 3

      See identical proteins and their annotated locations for NP_722490.1

      Status: VALIDATED

      Source sequence(s)
      AC163098, AK142912
      Consensus CDS
      CCDS29518.1
      UniProtKB/Swiss-Prot
      Q8K1B8
      UniProtKB/TrEMBL
      Q3TEE6
      Related
      ENSMUSP00000037858.9, ENSMUST00000040772.9
      Conserved Domains (4) summary
      smart00295
      Location:221 → 301
      B41; Band 4.1 homologues
      cd01237
      Location:350 → 474
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:550 → 641
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      pfam00373
      Location:490 → 555
      FERM_M; FERM central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6976326..6996837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1B8.1 GenPept UniProtKB/Swiss-Prot:Q8K1B8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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