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    Rab11fip4 RAB11 family interacting protein 4 (class II) [ Mus musculus (house mouse) ]

    Gene ID: 268451, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rab11fip4provided by MGI
    Official Full Name
    RAB11 family interacting protein 4 (class II)provided by MGI
    Primary source
    MGI:MGI:2442920
    See related
    Ensembl:ENSMUSG00000017639 AllianceGenome:MGI:2442920
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1821; RAB11-FIP4; A730072L08Rik
    Summary
    Predicted to enable protein homodimerization activity and small GTPase binding activity. Acts upstream of or within neural retina development and positive regulation of G1 to G0 transition. Located in perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; gut; respiratory system; sensory organ; and skeleton. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 31.5), frontal lobe adult (RPKM 30.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 46.88 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79481847..79588842)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79591021..79698016)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene STARR-positive B cell enhancer ABC_E8431 Neighboring gene STARR-positive B cell enhancer ABC_E7024 Neighboring gene STARR-positive B cell enhancer ABC_E5254 Neighboring gene STARR-positive B cell enhancer ABC_E11485 Neighboring gene ecotropic viral integration site 2b Neighboring gene ecotropic viral integration site 2 Neighboring gene ecotropic viral integration site 2a Neighboring gene STARR-positive B cell enhancer ABC_E11768 Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79428461-79428644 Neighboring gene predicted gene, 23293 Neighboring gene STARR-seq mESC enhancer starr_30126 Neighboring gene predicted gene, 25867 Neighboring gene predicted gene, 30718 Neighboring gene predicted gene, 24887 Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E9141 Neighboring gene nuclear encoded tRNA threonine 3 (anticodon CGT) Neighboring gene predicted gene 11205 Neighboring gene microRNA 193a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation. Hara Y, et al. Eur J Neurosci, 2018 Nov. PMID 30295969
    2. Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis. Wang JZ, et al. Mol Med Rep, 2018 Mar. PMID 29257314
    3. ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin. Hara Y, et al. eNeuro, 2016 Jul-Aug. PMID 27622210, Free PMC Article
    4. Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner. Muto A, et al. Dev Dyn, 2007 Jan. PMID 17089410
    5. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. Venturin M, et al. Ann Hum Genet, 2005 Sep. PMID 16138909

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FIP4 and FIP3 play overlapping but distinct roles in neuronal migration downstream of Rab11 and Arfophilin-1 during cortical layer formation.
      Title: FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation.
    2. Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis.
      Title: Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis.
    3. identification of Rab11-family interacting protein 4 (Rab11-FIP4) as a gene strongly expressed in the developing mouse retina.
      Title: Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1821

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rab11 family-interacting protein 4
    Names
    FIP4-Rab11
    mRab11-FIP4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175543.3 → NP_780752.1  rab11 family-interacting protein 4

      See identical proteins and their annotated locations for NP_780752.1

      Status: PROVISIONAL

      Source sequence(s)
      AK046734
      Consensus CDS
      CCDS25123.1
      UniProtKB/Swiss-Prot
      Q80T87, Q8BQP8
      Related
      ENSMUSP00000017783.7, ENSMUST00000017783.13
      Conserved Domains (3) summary
      pfam09457
      Location:594 → 634
      RBD-FIP; FIP domain
      pfam13499
      Location:21 → 78
      EF-hand_7; EF-hand domain pair
      cl03075
      Location:426 → 510
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      79481847..79588842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533403.2 → XP_006533466.1  rab11 family-interacting protein 4 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:315 → 545
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09457
      Location:571 → 611
      RBD-FIP; FIP domain
      pfam13499
      Location:20 → 78
      EF-hand_7; EF-hand domain pair

    2. XM_036156717.1 → XP_036012610.1  rab11 family-interacting protein 4 isoform X2

      Conserved Domains (2) summary
      TIGR02168
      Location:278 → 560
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09457
      Location:535 → 575
      RBD-FIP; FIP domain

    3. XM_036156719.1 → XP_036012612.1  rab11 family-interacting protein 4 isoform X5

      Conserved Domains (1) summary
      pfam13499
      Location:20 → 78
      EF-hand_7; EF-hand domain pair

    4. XM_030246035.2 → XP_030101895.1  rab11 family-interacting protein 4 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:199 → 429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09457
      Location:455 → 495
      RBD-FIP; FIP domain

    5. XM_006533404.4 → XP_006533467.1  rab11 family-interacting protein 4 isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:236 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09457
      Location:492 → 532
      RBD-FIP; FIP domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQP8.1 GenPept UniProtKB/Swiss-Prot:Q8BQP8

    Gene LinkOut

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