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    Zw10 zw10 kinetochore protein [ Mus musculus (house mouse) ]

    Gene ID: 26951, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zw10provided by MGI
    Official Full Name
    zw10 kinetochore proteinprovided by MGI
    Primary source
    MGI:MGI:1349478
    See related
    Ensembl:ENSMUSG00000032264 AllianceGenome:MGI:1349478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MmZw10; 6330566F14Rik
    Summary
    Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase plate congression; and regulation of mitotic cell cycle phase transition. Predicted to act upstream of or within cell division; protein transport; and vesicle-mediated transport. Predicted to be located in several cellular components, including kinetochore; lipid droplet; and spindle. Predicted to be part of Dsl1/NZR complex and RZZ complex. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.1), limb E14.5 (RPKM 13.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.3; 9 26.58 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48966880..48990075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (49055576..49078775)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene predicted gene, 53522 Neighboring gene STARR-seq mESC enhancer starr_24085 Neighboring gene claudin 25 Neighboring gene STARR-seq mESC enhancer starr_24086 Neighboring gene transmembrane protease, serine 5 (spinesin) Neighboring gene STARR-seq mESC enhancer starr_24087 Neighboring gene STARR-seq mESC enhancer starr_24088 Neighboring gene STARR-seq mESC enhancer starr_24089 Neighboring gene predicted gene 4894

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes. Park Y, et al. Histochem Cell Biol, 2019 Sep. PMID 31250100
    2. Conservation of the centromere/kinetochore protein ZW10. Starr DA, et al. J Cell Biol, 1997 Sep 22. PMID 9298984, Free PMC Article
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RZZ complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centromere/kinetochore protein zw10 homolog
    Names
    ZW10 homolog, centromere/kinetochore protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012039.2 → NP_036169.1  centromere/kinetochore protein zw10 homolog

      See identical proteins and their annotated locations for NP_036169.1

      Status: VALIDATED

      Source sequence(s)
      AK168479, BC067405, CJ172982
      Consensus CDS
      CCDS23161.1
      UniProtKB/Swiss-Prot
      O54692, Q3TIA5, Q3ULW1, Q921H3
      Related
      ENSMUSP00000034803.9, ENSMUST00000034803.10
      Conserved Domains (2) summary
      pfam06248
      Location:9 → 621
      Zw10; Centromere/kinetochore Zw10
      cl21453
      Location:598 → 768
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      48966880..48990075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510371.4 → XP_006510434.1  centromere/kinetochore protein zw10 homolog isoform X1

      Conserved Domains (2) summary
      pfam06248
      Location:5 → 347
      Zw10; Centromere/kinetochore Zw10
      cl21453
      Location:381 → 551
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54692.3 GenPept UniProtKB/Swiss-Prot:O54692

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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