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    Steap2 six transmembrane epithelial antigen of prostate 2 [ Mus musculus (house mouse) ]

    Gene ID: 74051, updated on 12-May-2024

    Summary

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    Official Symbol
    Steap2provided by MGI
    Official Full Name
    six transmembrane epithelial antigen of prostate 2provided by MGI
    Primary source
    MGI:MGI:1921301
    See related
    Ensembl:ENSMUSG00000015653 AllianceGenome:MGI:1921301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    STMP; IPCA1; IPCA-1; STAMP1; PCANAP1; 4921538B17Rik
    Summary
    Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within copper ion import across plasma membrane; iron ion import across cell outer membrane; and iron ion import across plasma membrane. Located in endosome and plasma membrane. Is expressed in several structures, including brain; gut; metanephros; reproductive system; and respiratory system. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 8.7), cerebellum adult (RPKM 4.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 A1; 5 3.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (5714829..5744649, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (5664829..5694649, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 237, member B Neighboring gene cilia and flagella associated protein 69 Neighboring gene predicted gene, 40262 Neighboring gene STARR-seq mESC enhancer starr_12346 Neighboring gene STARR-seq mESC enhancer starr_12348 Neighboring gene STARR-seq mESC enhancer starr_12350 Neighboring gene STARR-seq mESC enhancer starr_12351 Neighboring gene six transmembrane epithelial antigen of the prostate 1 Neighboring gene predicted gene, 46900 Neighboring gene STARR-seq mESC enhancer starr_12352 Neighboring gene heat shock protein 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway. Ji L, et al. Folia Histochem Cytobiol, 2023. PMID 36583372
    2. Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution. Hasegawa H, et al. Exp Cell Res, 2018 Sep 15. PMID 29940176
    3. Differential expression and function of stamp family proteins in adipocyte differentiation. Sikkeland J, et al. PLoS One, 2013. PMID 23874564, Free PMC Article
    4. STAMPing at the crossroads of normal physiology and disease states. Sikkeland J, et al. Mol Cell Endocrinol, 2016 Apr 15. PMID 26911931
    5. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. Vaghjiani RJ, et al. Tissue Eng Part A, 2009 Aug. PMID 19196137

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-kappaB pathway.
      Title: Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.
    2. The conformational modulation of STEAP2 by the local membrane cholesterol content can therefore serve as a potential mechanism to modulate STEAP2 function in a compartment-restricted manner
      Title: Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.
    3. Stamp1 and Stamp2 play critical roles in adipogenesis, but through different mechanisms.
      Title: Differential expression and function of stamp family proteins in adipocyte differentiation.
    4. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice.
      Title: Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cupric reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cupric reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferric-chelate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric-chelate reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within copper ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within copper ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within iron ion import across cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metalloreductase STEAP2
    NP_001096626.1
    NP_001096627.1
    NP_001272398.1
    NP_001272399.1
    NP_001272400.1
    NP_083010.2
    XP_011238977.1
    XP_030110704.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103156.2 → NP_001096626.1  metalloreductase STEAP2 isoform 1

      See identical proteins and their annotated locations for NP_001096626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC092404, AK015015, AK052981, CJ122203
      Consensus CDS
      CCDS39007.1
      UniProtKB/Swiss-Prot
      Q3TS12, Q8BWB6
      UniProtKB/TrEMBL
      B2RX33, D3Z1C4
      Related
      ENSMUSP00000015797.5, ENSMUST00000015797.11
      Conserved Domains (2) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component

    2. NM_001103157.2 → NP_001096627.1  metalloreductase STEAP2 isoform 1

      See identical proteins and their annotated locations for NP_001096627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC092404, AK015015, AK052981, AK086787, CJ101909, CJ122203
      Consensus CDS
      CCDS39007.1
      UniProtKB/Swiss-Prot
      Q3TS12, Q8BWB6
      UniProtKB/TrEMBL
      B2RX33, D3Z1C4
      Related
      ENSMUSP00000111085.3, ENSMUST00000115425.9
      Conserved Domains (2) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component

    3. NM_001285469.1 → NP_001272398.1  metalloreductase STEAP2 isoform 1

      See identical proteins and their annotated locations for NP_001272398.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC092404
      Consensus CDS
      CCDS39007.1
      UniProtKB/Swiss-Prot
      Q3TS12, Q8BWB6
      UniProtKB/TrEMBL
      B2RX33, D3Z1C4
      Related
      ENSMUSP00000116910.2, ENSMUST00000148333.8
      Conserved Domains (2) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component

    4. NM_001285470.1 → NP_001272399.1  metalloreductase STEAP2 isoform 1

      See identical proteins and their annotated locations for NP_001272399.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC092404, AK015015, AK162343, CJ122203
      Consensus CDS
      CCDS39007.1
      UniProtKB/Swiss-Prot
      Q3TS12, Q8BWB6
      UniProtKB/TrEMBL
      B2RX33, D3Z1C4
      Related
      ENSMUSP00000111084.3, ENSMUST00000115424.9
      Conserved Domains (2) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component

    5. NM_001285471.1 → NP_001272400.1  metalloreductase STEAP2 isoform 2

      See identical proteins and their annotated locations for NP_001272400.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC092404
      Consensus CDS
      CCDS71541.1
      UniProtKB/TrEMBL
      D3YUM6, D3Z1C4
      Related
      ENSMUSP00000111087.2, ENSMUST00000115427.8
      Conserved Domains (3) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 395
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:33 → 118
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

    6. NM_028734.5 → NP_083010.2  metalloreductase STEAP2 isoform 1

      See identical proteins and their annotated locations for NP_083010.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
      Source sequence(s)
      AC092404, AK015015, AK052981
      Consensus CDS
      CCDS39007.1
      UniProtKB/Swiss-Prot
      Q3TS12, Q8BWB6
      UniProtKB/TrEMBL
      B2RX33, D3Z1C4
      Related
      ENSMUSP00000111086.3, ENSMUST00000115426.9
      Conserved Domains (2) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      5714829..5744649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254844.2 → XP_030110704.1  metalloreductase STEAP2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TS12, Q8BWB6
      UniProtKB/TrEMBL
      B2RX33, D3Z1C4
      Conserved Domains (2) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component

    2. XM_011240675.4 → XP_011238977.1  metalloreductase STEAP2 isoform X1

      See identical proteins and their annotated locations for XP_011238977.1

      UniProtKB/Swiss-Prot
      Q3TS12, Q8BWB6
      UniProtKB/TrEMBL
      B2RX33, D3Z1C4
      Conserved Domains (2) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWB6.1 GenPept UniProtKB/Swiss-Prot:Q8BWB6

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