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    Slc20a1 solute carrier family 20, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20515, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc20a1provided by MGI
    Official Full Name
    solute carrier family 20, member 1provided by MGI
    Primary source
    MGI:MGI:108392
    See related
    Ensembl:ENSMUSG00000027397 AllianceGenome:MGI:108392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glvr1; Glvr-1
    Summary
    Predicted to enable high-affinity inorganic phosphate:sodium symporter activity and inorganic phosphate transmembrane transporter activity. Acts upstream of or within biomineral tissue development. Located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; liver; and nervous system. Orthologous to human SLC20A1 (solute carrier family 20 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 22.0), frontal lobe adult (RPKM 18.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 62.79 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129038662..129053535)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129198773..129211615)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05661 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:129005758-129006030 Neighboring gene expressed sequence AI847159 Neighboring gene predicted gene, 39932 Neighboring gene STARR-positive B cell enhancer ABC_E3404 Neighboring gene RIKEN cDNA A730036I17 gene Neighboring gene STARR-seq mESC enhancer starr_05664 Neighboring gene STARR-seq mESC enhancer starr_05666 Neighboring gene STARR-positive B cell enhancer ABC_E5981 Neighboring gene STARR-positive B cell enhancer ABC_E7862 Neighboring gene cytoskeleton associated protein 2-like Neighboring gene STARR-seq mESC enhancer starr_05668

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PiT1/Slc20a1 Is Required for Endoplasmic Reticulum Homeostasis, Chondrocyte Survival, and Skeletal Development. Couasnay G, et al. J Bone Miner Res, 2019 Feb. PMID 30347511
    2. Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells. Chavkin NW, et al. Exp Cell Res, 2015 Apr 10. PMID 25684711, Free PMC Article
    3. Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development. Liu L, et al. Exp Hematol, 2013 May. PMID 23376999, Free PMC Article
    4. Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter. Sekiguchi S, et al. Am J Physiol Renal Physiol, 2011 Apr. PMID 21307129
    5. The role of pyrophosphate/phosphate homeostasis in terminal differentiation and apoptosis of growth plate chondrocytes. Kim HJ, et al. Bone, 2010 Sep. PMID 20601283, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.
      Title: Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.
    2. Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.
      Title: Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.
    3. data thus reveal a novel, Pi-transport independent function of PiT1, as a critical modulator of ER homeostasis and chondrocyte survival during endochondral ossification.
      Title: PiT1/Slc20a1 Is Required for Endoplasmic Reticulum Homeostasis, Chondrocyte Survival, and Skeletal Development.
    4. These data support the involvement of phosphate transporter 1, hereafter referred to as Pi T-1, in the initiation of skeletal mineralization and provide compelling evidence that PHOSPHO1 function is involved in MV biogenesis
      Title: Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.
    5. propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the yolk sac visceral endoderm
      Title: Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.
    6. Pi uptake-dependent and -independent functions of PiT-1 are important for vascular smooth muscle cell processes mediating vascular calcification.
      Title: Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells.
    7. Mechanistically, PiT-1 and PiT-2 seem to serve redundant roles in phosphate-induced calcification of vascular smooth muscle cells.
      Title: Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.
    8. Data indicate that mice lacking SLC20A1 (PiT1) develop a profound underproduction anemia characterized by mild macrocytosis, dyserythropoiesis, increased apoptosis, and a near complete block in terminal erythroid differentiation.
      Title: Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development.
    9. Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1.
      Title: Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1.
    10. that cellular ATP synthesis consequent to P(i) uptake via Pit-1 plays an important role in chondrocyte apoptosis and mineralization, and that chondrogenesis is ATP-dependent.
      Title: Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables high-affinity phosphate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:phosphate symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within biomineral tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent phosphate transporter 1
    Names
    gibbon ape leukemia virus receptor 1
    leukemia virus receptor 1 homolog
    phosphate transporter 1
    piT-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159593.2 → NP_001153065.1  sodium-dependent phosphate transporter 1 isoform 2

      See identical proteins and their annotated locations for NP_001153065.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL772347
      UniProtKB/Swiss-Prot
      Q61609
      Related
      ENSMUST00000141285.2
      Conserved Domains (2) summary
      COG0306
      Location:25 → 214
      PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]
      pfam01384
      Location:46 → 148
      PHO4; Phosphate transporter family

    2. NM_001355252.1 → NP_001342181.1  sodium-dependent phosphate transporter 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL772347
      Conserved Domains (1) summary
      pfam01384
      Location:247 → 392
      PHO4; Phosphate transporter family

    3. NM_015747.3 → NP_056562.1  sodium-dependent phosphate transporter 1 isoform 1

      See identical proteins and their annotated locations for NP_056562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL772347
      Consensus CDS
      CCDS16722.1
      UniProtKB/Swiss-Prot
      A2AKR9, Q3U244, Q61609, Q8CBJ1, Q91YQ9, Q9QVW6
      Related
      ENSMUSP00000028880.4, ENSMUST00000028880.10
      Conserved Domains (1) summary
      pfam01384
      Location:509 → 667
      PHO4; Phosphate transporter family

    RNA

    1. NR_185225.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772347

    2. NR_185226.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772347

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129038662..129053535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159901.1 → XP_036015794.1  sodium-dependent phosphate transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AKR9, Q3U244, Q61609, Q8CBJ1, Q91YQ9, Q9QVW6
      Conserved Domains (1) summary
      pfam01384
      Location:509 → 667
      PHO4; Phosphate transporter family

    RNA

    1. XR_004939188.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61609.1 GenPept UniProtKB/Swiss-Prot:Q61609

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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