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    Slc16a5 solute carrier family 16 (monocarboxylic acid transporters), member 5 [ Mus musculus (house mouse) ]

    Gene ID: 217316, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc16a5provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 5provided by MGI
    Primary source
    MGI:MGI:2443515
    See related
    Ensembl:ENSMUSG00000045775 AllianceGenome:MGI:2443515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCT5; MCT 5; MCT 6; A130015N09Rik
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 51.1), duodenum adult (RPKM 26.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 80.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115353231..115365224)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115462405..115474398)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1435 Neighboring gene potassium channel tetramerisation domain containing 2 Neighboring gene tripartite motif-containing 80 Neighboring gene microRNA 3968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115323680-115323881 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324075-115324262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324966-115325149 Neighboring gene predicted gene 11695 Neighboring gene STARR-positive B cell enhancer ABC_E5298 Neighboring gene armadillo repeat containing 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115353318-115353427 Neighboring gene ribosomal protein L39 pseudogene Neighboring gene 5',3'-nucleotidase, cytosolic

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism. Jones RS, et al. Mol Pharmacol, 2019 Sep. PMID 31436537, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 6
    Names
    monocarboxylate transporter 5
    solute carrier family 16 member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080934.1 → NP_001074403.1  monocarboxylate transporter 6 isoform 1

      See identical proteins and their annotated locations for NP_001074403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL645470
      Consensus CDS
      CCDS36373.1
      UniProtKB/Swiss-Prot
      A2A9X8, A2A9X9, A2A9Y0, G5E8K6
      Related
      ENSMUSP00000090102.6, ENSMUST00000092445.12
      Conserved Domains (2) summary
      cd06174
      Location:32 → 413
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:8 → 461
      2A0113; monocarboxylate transporter 1

    2. NM_001359606.1 → NP_001346535.1  monocarboxylate transporter 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK037416, AK079757, BC052932
      Conserved Domains (1) summary
      TIGR00892
      Location:1 → 326
      2A0113; monocarboxylate transporter 1

    3. NM_001359608.1 → NP_001346537.1  monocarboxylate transporter 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two coding exons, compared to variant 1. It encodes isoform 3, which lacks a large internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK079757, BC052932
      Consensus CDS
      CCDS88283.1
      UniProtKB/TrEMBL
      A0A0A0MQC4
      Related
      ENSMUSP00000102142.4, ENSMUST00000106532.4
      Conserved Domains (1) summary
      cl26868
      Location:8 → 94
      2A0111; oxalate/formate antiporter family transporter

    4. NM_001359609.1 → NP_001346538.1  monocarboxylate transporter 6 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the use of an alternate promoter compared to variant 1. It differs in the 5' UTR, uses a downstream start codon and lacks a coding exon, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      BC052932
      Related
      ENSMUST00000133636.8
      Conserved Domains (1) summary
      cl26868
      Location:1 → 34
      2A0111; oxalate/formate antiporter family transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115353231..115365224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245893.1 → XP_030101753.1  monocarboxylate transporter 6 isoform X3

      Conserved Domains (2) summary
      TIGR00892
      Location:115 → 190
      2A0113; monocarboxylate transporter 1
      cl28910
      Location:13 → 116
      MFS; Major Facilitator Superfamily

    2. XM_006533082.4 → XP_006533145.1  monocarboxylate transporter 6 isoform X2

      See identical proteins and their annotated locations for XP_006533145.1

      Conserved Domains (1) summary
      TIGR00892
      Location:1 → 326
      2A0113; monocarboxylate transporter 1

    3. XM_006533080.4 → XP_006533143.1  monocarboxylate transporter 6 isoform X1

      Conserved Domains (1) summary
      TIGR00892
      Location:1 → 379
      2A0113; monocarboxylate transporter 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E8K6.1 GenPept UniProtKB/Swiss-Prot:G5E8K6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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