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    Cdc37l1 cell division cycle 37-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 67072, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cdc37l1provided by MGI
    Official Full Name
    cell division cycle 37-like 1provided by MGI
    Primary source
    MGI:MGI:1914322
    See related
    Ensembl:ENSMUSG00000024780 AllianceGenome:MGI:1914322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Harc; Cdc37l; 2700033A15Rik
    Summary
    This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.6), cortex adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc37l1 in Genome Data Viewer
    Location:
    19 C1; 19 23.61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28959049..29008832)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28990337..29026664)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase pseudogene Neighboring gene tektin 5 like Neighboring gene adenylate kinase 3 Neighboring gene STARR-seq mESC enhancer starr_45875 Neighboring gene ribosomal protein L26 pseudogene Neighboring gene RIKEN cDNA 1700018L02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1523 Neighboring gene STARR-seq mESC enhancer starr_45878 Neighboring gene predicted gene 9895

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock. Cartledge K, et al. Biochemistry, 2007 Dec 25. PMID 18052042
    2. Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. Scholz GM, et al. J Biol Chem, 2001 Aug 17. PMID 11413142
    3. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article
    4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hsp90 co-chaperone Cdc37-like 1
    Names
    Hsp90-associating relative of Cdc37
    cell division cycle 37 homolog-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302380.2 → NP_001289309.1  hsp90 co-chaperone Cdc37-like 1 isoform 2

      See identical proteins and their annotated locations for NP_001289309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC113961
      Consensus CDS
      CCDS89372.1
      UniProtKB/TrEMBL
      A0A286YCB4
      Related
      ENSMUSP00000152985.2, ENSMUST00000224511.2
      Conserved Domains (2) summary
      smart01070
      Location:138 → 280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71 → 139
      CDC37_N; Cdc37 N terminal kinase binding

    2. NM_001302382.2 → NP_001289311.1  hsp90 co-chaperone Cdc37-like 1 isoform 3

      See identical proteins and their annotated locations for NP_001289311.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC113961
      Consensus CDS
      CCDS89371.1
      UniProtKB/TrEMBL
      A0A286YCB4
      Related
      ENSMUSP00000153192.2, ENSMUST00000225310.2
      Conserved Domains (2) summary
      smart01070
      Location:138 → 280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71 → 139
      CDC37_N; Cdc37 N terminal kinase binding

    3. NM_001302443.2 → NP_001289372.1  hsp90 co-chaperone Cdc37-like 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC113961
      UniProtKB/Swiss-Prot
      Q9CZP7
      Conserved Domains (2) summary
      smart01070
      Location:138 → 280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71 → 139
      CDC37_N; Cdc37 N terminal kinase binding

    4. NM_001377047.1 → NP_001363976.1  hsp90 co-chaperone Cdc37-like 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC113961
      Conserved Domains (2) summary
      smart01070
      Location:138 → 280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71 → 139
      CDC37_N; Cdc37 N terminal kinase binding

    5. NM_025950.4 → NP_080226.1  hsp90 co-chaperone Cdc37-like 1 isoform 1

      See identical proteins and their annotated locations for NP_080226.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC113961
      Consensus CDS
      CCDS29729.1
      UniProtKB/Swiss-Prot
      Q3TNC7, Q8BP15, Q8C892, Q8C8X2, Q9CU15, Q9CZP7
      Related
      ENSMUSP00000060421.4, ENSMUST00000050148.5
      Conserved Domains (2) summary
      smart01070
      Location:138 → 280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71 → 139
      CDC37_N; Cdc37 N terminal kinase binding

    RNA

    1. NR_165053.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC113961

    2. NR_165054.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC113961

    3. NR_165055.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC113961

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      28959049..29008832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940168.1 RNA Sequence

    2. XR_003952810.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZP7.1 GenPept UniProtKB/Swiss-Prot:Q9CZP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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