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    Prkra protein kinase, interferon inducible double stranded RNA dependent activator [ Mus musculus (house mouse) ]

    Gene ID: 23992, updated on 23-Jun-2021

    Summary

    Official Symbol
    Prkraprovided by MGI
    Official Full Name
    protein kinase, interferon inducible double stranded RNA dependent activatorprovided by MGI
    Primary source
    MGI:MGI:1344375
    See related
    Ensembl:ENSMUSG00000002731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; R; l; Pa; PRK; RAX; Pact; lear; AV120107
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.2), CNS E14 (RPKM 14.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prkra in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76436385..76478614, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76609215..76648220, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (76467994..76486051, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 45 Neighboring gene oxysterol binding protein-like 6 Neighboring gene pejvakin Neighboring gene FK506 binding protein 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pre-miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interferon-inducible double-stranded RNA-dependent protein kinase activator A
    Names
    PKR-associated protein X
    PKR-associating protein X
    protein activator of the interferon-induced protein kinase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011871.3NP_036001.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A

      See identical proteins and their annotated locations for NP_036001.1

      Status: VALIDATED

      Source sequence(s)
      AL928867
      Consensus CDS
      CCDS16159.1
      UniProtKB/Swiss-Prot
      Q9WTX2
      Related
      ENSMUSP00000002808.7, ENSMUST00000002808.7
      Conserved Domains (3) summary
      cd19889
      Location:32102
      DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19891
      Location:126192
      DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19892
      Location:239310
      DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76436385..76478614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250934.2XP_030106794.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X1

      Conserved Domains (3) summary
      cd19889
      Location:113183
      DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19891
      Location:207273
      DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cl00054
      Location:320350
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    2. XM_017318023.3XP_017173512.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X3

      Conserved Domains (2) summary
      cd19891
      Location:1379
      DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19892
      Location:126197
      DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    3. XM_030250935.2XP_030106795.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X2

      Conserved Domains (3) summary
      cd19889
      Location:113183
      DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19891
      Location:207273
      DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cl00054
      Location:320342
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
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