Ndst1 N-deacetylase and N-sulfotransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndst1provided by RGD
Official Full Name: N-deacetylase and N-sulfotransferase 1provided by RGD
Primary source: RGD:69303
See related: Ensembl:ENSRNOG00000019014 AllianceGenome:RGD:69303
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsst; N-HSST
Summary: Enables [heparan sulfate]-glucosamine N-sulfotransferase activity and heparan sulfate N-deacetylase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 385.5), Kidney (RPKM 339.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (56407308..56470007, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (54136887..54199545, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (55951497..56014107, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role and mechanism of NDST1/NULP1 regulating right ventricular hypertrophy in hypoxic pulmonary hypertension.
Title: The role and mechanism of NDST1/NULP1 regulating right ventricular hypertrophy in hypoxic pulmonary hypertension.
Relative mRNA expression of Ndst1 and Slit3 was significantly decreased in pleuroperitoneal folds, developing diaphragms and fully muscularized diaphragms, and endothelial cells within the diaphragmatic vasculature of nitrofen-exposed fetuses compared to controls.
Title: Down-regulation of N-deacetylase-N-sulfotransferase-1 signaling in the developing diaphragmatic vasculature of nitrofen-induced congenital diaphragmatic hernia.
the regulating role of NDST-1 in mapping the sulfation patterns of HS.
Title: The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate.
The regulation of NDST1 by angiotensin II in diabetic rats is reported.
Title: Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II.
The Ndst1 is a critical enzyme involved in heparan sulfate/heparin biosynthesis.
Title: Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1).

Submit: New GeneRIF Correction

General gene information

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Markers

Ndst1 (e-PCR), detects polymorphism
- UniSTS:225833

Ndst1 (e-PCR), detects polymorphism
- UniSTS:532560

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylglucosamine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables heparan sulfate N-deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables heparan sulfate N-deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heparan sulfate N-deacetylase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic neurocranium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycosaminoglycan metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within midbrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within polysaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

Names: Golgi heparan sulfate N-deacetylase/N-sulfotransferase; HSNST 1; N-HSST 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; N-deacetylase/N-sulfotransferase 1; N-heparan sulfate sulfotransferase 1; NDST-1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase

NP_077337.1

EC 2.8.2.8

XP_008770352.1

EC 2.8.2.8

XP_017456418.1

EC 2.8.2.8

XP_017456419.1

EC 2.8.2.8

XP_017456420.1

EC 2.8.2.8

XP_017456421.1

EC 2.8.2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024361.2 → NP_077337.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

See identical proteins and their annotated locations for NP_077337.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q02353

UniProtKB/TrEMBL

A6IXC4

Related

ENSRNOP00000025881.3, ENSRNOT00000025881.5

Conserved Domains (2) summary

pfam00685
Location:605 → 855

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:30 → 515

HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

56407308..56470007 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600932.3 → XP_017456421.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q02353

UniProtKB/TrEMBL

A6IXC4

Conserved Domains (2) summary

pfam00685
Location:605 → 855

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:30 → 515

HSNSD; heparan sulfate-N-deacetylase
XM_017600930.3 → XP_017456419.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q02353

UniProtKB/TrEMBL

A6IXC4

Conserved Domains (2) summary

pfam00685
Location:605 → 855

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:30 → 515

HSNSD; heparan sulfate-N-deacetylase
XM_017600929.3 → XP_017456418.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q02353

UniProtKB/TrEMBL

A6IXC4

Conserved Domains (2) summary

pfam00685
Location:605 → 855

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:30 → 515

HSNSD; heparan sulfate-N-deacetylase
XM_017600931.3 → XP_017456420.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q02353

UniProtKB/TrEMBL

A6IXC4

Conserved Domains (2) summary

pfam00685
Location:605 → 855

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:30 → 515

HSNSD; heparan sulfate-N-deacetylase
XM_008772130.4 → XP_008770352.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

Conserved Domains (2) summary

pfam00685
Location:181 → 431

Sulfotransfer_1; Sulfotransferase domain

pfam12062
Location:1 → 91

HSNSD; heparan sulfate-N-deacetylase