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    Pcdh7 protocadherin 7 [ Mus musculus (house mouse) ]

    Gene ID: 54216, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pcdh7provided by MGI
    Official Full Name
    protocadherin 7provided by MGI
    Primary source
    MGI:MGI:1860487
    See related
    Ensembl:ENSMUSG00000029108 AllianceGenome:MGI:1860487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in cell adhesion. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including bladder; central nervous system; dorsal root ganglion; gut; and olfactory epithelium. Orthologous to human PCDH7 (protocadherin 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 7.7), cortex adult (RPKM 7.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcdh7 in Genome Data Viewer
    Location:
    5 C1; 5 31.65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (57873487..58290578)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (57716145..58133236)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13126 Neighboring gene synaptosomal-associated protein 23 pseudogene Neighboring gene RIKEN cDNA 4932441J04 gene Neighboring gene STARR-seq mESC enhancer starr_13127 Neighboring gene STARR-seq mESC enhancer starr_13128 Neighboring gene STARR-seq mESC enhancer starr_13129 Neighboring gene IMP1 inner mitochondrial membrane peptidase-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_13130 Neighboring gene STARR-seq mESC enhancer starr_13131 Neighboring gene STARR-seq mESC enhancer starr_13132 Neighboring gene predicted gene, 17977 Neighboring gene predicted gene, 54319 Neighboring gene STARR-seq mESC enhancer starr_13133 Neighboring gene predicted gene, 22536

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation. Kim H, et al. BMB Rep, 2020 Sep. PMID 32635982, Free PMC Article
    2. cDNA cloning and chromosomal mapping of mouse BH-protocadherin. Yoshida K, et al. DNA Seq, 1999. PMID 10565544
    3. Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice. Messing A, et al. Am J Pathol, 1998 Feb. PMID 9466565, Free PMC Article
    4. Overexpression of protocadherin 7 inhibits neuronal survival by downregulating BIRC5 in vitro. Xiao H, et al. Exp Cell Res, 2018 May 1. PMID 29548751
    5. Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily. Yoshida K, et al. Genomics, 1998 May 1. PMID 9615233

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protocadherin-7 Regulates Osteoclast Differentiation through Intracellular SET-Binding Domain-Mediated RhoA and Rac1 Activation.
      Title: Protocadherin-7 Regulates Osteoclast Differentiation through Intracellular SET-Binding Domain-Mediated RhoA and Rac1 Activation.
    2. Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation.
      Title: Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation.
    3. The existence of Pcdh7-BIRC5 signaling cascade in the cortical neurons and represent a potential therapeutic area for further investigation.
      Title: Overexpression of protocadherin 7 inhibits neuronal survival by downregulating BIRC5 in vitro.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protocadherin-7
    Names
    BH-protocadherin (brain-heart)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122758.2 → NP_001116230.1  protocadherin-7 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC165316, AK039737, AK140356, AK165115
      Consensus CDS
      CCDS51505.1
      UniProtKB/TrEMBL
      A0A0A6YY83, Q3TVS7, Q3USI1
      Related
      ENSMUSP00000142319.2, ENSMUST00000191837.6
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    2. NM_001310606.1 → NP_001297535.1  protocadherin-7 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001297535.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC131036, AC163275, AC165316
      Consensus CDS
      CCDS80286.1
      UniProtKB/TrEMBL
      E9Q2S0, Q3TVS7, Q3USI1
      Related
      ENSMUSP00000092376.5, ENSMUST00000094783.7
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    3. NM_001310608.1 → NP_001297537.1  protocadherin-7 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' region, which results in a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a shorter and different C-terminus, compared to isoform 1.
      Source sequence(s)
      AC165316, AK140356, AK165115, CF746345
      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    4. NM_018764.3 → NP_061234.2  protocadherin-7 isoform 2 precursor

      See identical proteins and their annotated locations for NP_061234.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 3' coding exons and has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, compared to isoform 1.
      Source sequence(s)
      AC163275, AK140356, AK165115
      Consensus CDS
      CCDS19296.1
      UniProtKB/TrEMBL
      A2RS43, Q3TVS7, Q3USI1
      Related
      ENSMUSP00000066306.8, ENSMUST00000068110.10
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      57873487..58290578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504023.4 → XP_006504086.1  protocadherin-7 isoform X5

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    2. XM_006504019.4 → XP_006504082.1  protocadherin-7 isoform X1

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    3. XM_006504024.4 → XP_006504087.1  protocadherin-7 isoform X6

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    4. XM_006504020.4 → XP_006504083.1  protocadherin-7 isoform X2

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    5. XM_006504022.4 → XP_006504085.1  protocadherin-7 isoform X3

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    6. XM_006504029.4 → XP_006504092.1  protocadherin-7 isoform X12

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    7. XM_036165308.1 → XP_036021201.1  protocadherin-7 isoform X4

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    8. XM_006504030.4 → XP_006504093.1  protocadherin-7 isoform X13

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    9. XM_017320993.3 → XP_017176482.1  protocadherin-7 isoform X9

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    10. XM_006504025.4 → XP_006504088.1  protocadherin-7 isoform X7

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    11. XM_036165309.1 → XP_036021202.1  protocadherin-7 isoform X8

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    12. XM_006504028.4 → XP_006504091.1  protocadherin-7 isoform X10

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin

    13. XM_036165310.1 → XP_036021203.1  protocadherin-7 isoform X11

      UniProtKB/TrEMBL
      Q3TVS7, Q3USI1
      Conserved Domains (2) summary
      cd11304
      Location:541 → 635
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08374
      Location:842 → 1053
      Protocadherin
    Nucleotide Protein Strain
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