Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dpysl5 dihydropyrimidinase-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 65254, updated on 6-May-2021

    Summary

    Official Symbol
    Dpysl5provided by MGI
    Official Full Name
    dihydropyrimidinase-like 5provided by MGI
    Primary source
    MGI:MGI:1929772
    See related
    Ensembl:ENSMUSG00000029168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CR; Crm; CRAM; CRMP; Crmp5; CRMP-5
    Expression
    Biased expression in CNS E18 (RPKM 113.7), whole brain E14.5 (RPKM 105.1) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dpysl5 in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30868908..30956713)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30711564..30799369)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31014268..31101742)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene autophagy-related 3 pseudogene Neighboring gene predicted gene, 46907 Neighboring gene microtubule-associated protein, RP/EB family, member 3 Neighboring gene transmembrane protein 214

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in pyrimidine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dihydropyrimidinase-related protein 5
    Names
    DRP-5
    collapsin response mediator protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356948.1NP_001343877.1  dihydropyrimidinase-related protein 5 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC105298, AC109611
      Consensus CDS
      CCDS39047.1
      Related
      ENSMUSP00000110377.2, ENSMUST00000114729.8
      Conserved Domains (1) summary
      cd01314
      Location:10459
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
    2. NM_001356949.1NP_001343878.1  dihydropyrimidinase-related protein 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC105298, BC103789
      Consensus CDS
      CCDS89896.1
      Related
      ENSMUSP00000098985.4, ENSMUST00000101442.4
      Conserved Domains (1) summary
      cl00281
      Location:1087
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    3. NM_023047.3NP_075534.1  dihydropyrimidinase-related protein 5 isoform a

      See identical proteins and their annotated locations for NP_075534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC105298, BC065054
      Consensus CDS
      CCDS39047.1
      UniProtKB/Swiss-Prot
      Q9EQF6
      Related
      ENSMUSP00000085400.5, ENSMUST00000088081.11
      Conserved Domains (1) summary
      cd01314
      Location:10459
      D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30868908..30956713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center