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    Timm9 translocase of inner mitochondrial membrane 9 [ Mus musculus (house mouse) ]

    Gene ID: 30056, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Timm9provided by MGI
    Official Full Name
    translocase of inner mitochondrial membrane 9provided by MGI
    Primary source
    MGI:MGI:1353436
    See related
    Ensembl:ENSMUSG00000021079 AllianceGenome:MGI:1353436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tim10a; Timm10; 2810011L15Rik
    Summary
    Predicted to enable chaperone binding activity; membrane insertase activity; and protein homodimerization activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Part of mitochondrial intermembrane space protein transporter complex. Is expressed in genitourinary system; orbito-sphenoid; otic capsule; and telencephalon ventricular layer. Orthologous to human TIMM9 (translocase of inner mitochondrial membrane 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.2), frontal lobe adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Timm9 in Genome Data Viewer
    Location:
    12 C2; 12 29.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71169946..71183476, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (71123172..71136708, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110056K07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116322-72116431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116588-72116697 Neighboring gene STARR-seq mESC enhancer starr_32414 Neighboring gene AT-rich interaction domain 4A Neighboring gene STARR-positive B cell enhancer ABC_E7145 Neighboring gene STARR-seq mESC enhancer starr_32415 Neighboring gene RIKEN cDNA 2700049A03 gene Neighboring gene translocase of outer mitochondrial membrane 20-like Neighboring gene predicted gene, 32906 Neighboring gene STARR-positive B cell enhancer ABC_E918 Neighboring gene STARR-positive B cell enhancer ABC_E10758 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene 7959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. Jin H, et al. Genomics, 1999 Nov 1. PMID 10552927
    2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
    3. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
    4. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
    5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial intermembrane space protein transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim9
    Names
    translocase of inner mitochondrial membrane 10 homolog
    translocase of inner mitochondrial membrane 9 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024853.1 → NP_001020024.1  mitochondrial import inner membrane translocase subunit Tim9

      See identical proteins and their annotated locations for NP_001020024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AC159620, AI848414, DV652207
      Consensus CDS
      CCDS25962.1
      UniProtKB/Swiss-Prot
      Q9WV98
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. NM_001024854.1 → NP_001020025.1  mitochondrial import inner membrane translocase subunit Tim9

      See identical proteins and their annotated locations for NP_001020025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AC159620, AI848414, AK018764
      Consensus CDS
      CCDS25962.1
      UniProtKB/Swiss-Prot
      Q9WV98
      Related
      ENSMUSP00000021486.9, ENSMUST00000021486.10
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    3. NM_001286203.2 → NP_001273132.1  mitochondrial import inner membrane translocase subunit Tim9

      See identical proteins and their annotated locations for NP_001273132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AC159620, AF150101, AI848414
      Consensus CDS
      CCDS25962.1
      UniProtKB/Swiss-Prot
      Q9WV98
      Related
      ENSMUSP00000152455.2, ENSMUST00000221559.2
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    4. NM_013896.3 → NP_038924.1  mitochondrial import inner membrane translocase subunit Tim9

      See identical proteins and their annotated locations for NP_038924.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AC159620, AI119857, AI848414, CK626183
      Consensus CDS
      CCDS25962.1
      UniProtKB/Swiss-Prot
      Q9WV98
      Related
      ENSMUSP00000126298.2, ENSMUST00000166120.9
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      71169946..71183476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157467.1 → XP_036013360.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

      UniProtKB/Swiss-Prot
      Q9WV98
      Related
      ENSMUSP00000152114.2, ENSMUST00000220482.2
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. XM_011244122.4 → XP_011242424.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

      See identical proteins and their annotated locations for XP_011242424.1

      UniProtKB/Swiss-Prot
      Q9WV98
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    3. XM_036157466.1 → XP_036013359.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

      UniProtKB/Swiss-Prot
      Q9WV98
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    4. XM_017315088.3 → XP_017170577.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

      UniProtKB/Swiss-Prot
      Q9WV98
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV98.1 GenPept UniProtKB/Swiss-Prot:Q9WV98

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