Cx3cr1 C-X3-C motif chemokine receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cx3cr1provided by MGI
Official Full Name: C-X3-C motif chemokine receptor 1provided by MGI
Primary source: MGI:MGI:1333815
See related: Ensembl:ENSMUSG00000052336 AllianceGenome:MGI:1333815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mCX3CR1
Summary: Enables C-X3-C chemokine binding activity and C-X3-C chemokine receptor activity. Involved in several processes, including leukocyte migration; nervous system development; and synapse organization. Acts upstream of or within several processes, including macrophage chemotaxis; microglial cell activation involved in immune response; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cell surface. Is expressed in several structures, including colon; genitourinary system; and liver. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 8.3), frontal lobe adult (RPKM 7.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 71.37 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (119877749..119897362, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (120048683..120068296, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina.
Title: Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina.
FKN secreted by kidney epithelial cells regulates macrophage activation in lupus nephritis via the Hippo signaling pathway.
Title: FKN secreted by kidney epithelial cells regulates macrophage activation in lupus nephritis via the Hippo signaling pathway.
CX3CR1 mediates motor dysfunction in mice through 5-HTR2a.
Title: CX3CR1 mediates motor dysfunction in mice through 5-HTR2a.
Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1.
Title: Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1.
CX3CL1 represses autophagy via CX3CR1/ CaMKIIdelta/HDAC4/Rubicon axis and exacerbates chronic intermittent hypoxia induced Kupffer cell apoptosis.
Title: CX3CL1 represses autophagy via CX3CR1/ CaMKIIδ/HDAC4/Rubicon axis and exacerbates chronic intermittent hypoxia induced Kupffer cell apoptosis.
Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling.
Title: Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling.
CX3CR1 regulates the development of renal interstitial fibrosis through macrophage polarization.
Title: CX3CR1 regulates the development of renal interstitial fibrosis through macrophage polarization.
Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.
Title: Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.
Microglial LRRK2-mediated NFATc1 attenuates alpha-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.
Title: Microglial LRRK2-mediated NFATc1 attenuates α-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.
Influence of CX3CR1 Deletion on Cochlear Hair Cell Survival and Macrophage Expression in Chronic Suppurative Otitis Media.
Title: Influence of CX3CR1 Deletion on Cochlear Hair Cell Survival and Macrophage Expression in Chronic Suppurative Otitis Media.

Submit: New GeneRIF Correction See all GeneRIFs (252)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (15) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X3-C chemokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-X3-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables C-X3-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables CX3C chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in autocrine signaling	ISO Inferred from Sequence Orthology more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IPI Inferred from Physical Interaction more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in central nervous system maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in host-mediated regulation of intestinal microbiota composition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IC Inferred by Curator more info	PubMed
involved_in leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte tethering or rolling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multiple spine synapse organization, single dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chronic inflammatory response to non-antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippocampal neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microglial cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric oxide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic tree	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CX3C chemokine receptor 1

Names: C-X3-C CKR-1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; fractalkine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.