Bzw1 basic leucine zipper and W2 domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bzw1provided by MGI
Official Full Name: basic leucine zipper and W2 domains 1provided by MGI
Primary source: MGI:MGI:1914132
See related: Ensembl:ENSMUSG00000051223 AllianceGenome:MGI:1914132
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0005; 1200015E15Rik
Summary: Predicted to be active in cytoplasm. Orthologous to human BZW1 (basic leucine zipper and W2 domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 69.8), CNS E18 (RPKM 52.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.3; 1 29.09 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (58432057..58446513)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (58392898..58407354)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
Title: Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.
Title: Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G54452 (e-PCR)
- UniSTS:140854

RH127595 (e-PCR)
- UniSTS:210905

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eIF5-mimic protein 2

Names: basic leucine zipper and W2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025824.4 → NP_080100.1 eIF5-mimic protein 2

See identical proteins and their annotated locations for NP_080100.1

Status: VALIDATED

Source sequence(s)

AC121091, AK076560, AK161192, CJ085444

Consensus CDS

CCDS14971.1

UniProtKB/Swiss-Prot

Q3THS5, Q3UZ94, Q9CQC6

Related

ENSMUSP00000051935.9, ENSMUST00000050552.15

Conserved Domains (1) summary

cd11560
Location:217 → 406

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

58432057..58446513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322066.1 → XP_017177555.1 eIF5-mimic protein 2 isoform X1

Conserved Domains (1) summary

cd11560
Location:133 → 322

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins