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    Aldoc aldolase C, fructose-bisphosphate [ Mus musculus (house mouse) ]

    Gene ID: 11676, updated on 5-Sep-2021

    Summary

    Official Symbol
    Aldocprovided by MGI
    Official Full Name
    aldolase C, fructose-bisphosphateprovided by MGI
    Primary source
    MGI:MGI:101863
    See related
    Ensembl:ENSMUSG00000017390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Al; Scr; Aldo3; Scrg2; AI847350; AU040929
    Summary
    This gene encodes a member of the aldolase family of enzymes that is mainly expressed in neuronal tissues. The encoded protein is an enzyme of the glycolysis pathway, and catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in cerebellum adult (RPKM 424.1), cortex adult (RPKM 249.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Aldoc in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78213899..78218607)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78323073..78327781)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (78137700..78140262)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase related Neighboring gene predicted gene 3948 Neighboring gene sperm associated antigen 5 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class S Neighboring gene unc-119 lipid binding chaperone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fructose-bisphosphate aldolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose-bisphosphate aldolase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aging ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    fructose-bisphosphate aldolase C
    Names
    brain-type aldolase
    scrapie responsive gene 2
    scrapie-responsive protein 2
    zebrin II
    NP_001290352.1
    NP_033787.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303423.1NP_001290352.1  fructose-bisphosphate aldolase C

      See identical proteins and their annotated locations for NP_001290352.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL591070
      Consensus CDS
      CCDS25099.1
      UniProtKB/Swiss-Prot
      P05063
      Related
      ENSMUSP00000017534.9, ENSMUST00000017534.15
      Conserved Domains (1) summary
      pfam00274
      Location:15363
      Glycolytic; Fructose-bisphosphate aldolase class-I
    2. NM_009657.4NP_033787.2  fructose-bisphosphate aldolase C

      See identical proteins and their annotated locations for NP_033787.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL591070
      Consensus CDS
      CCDS25099.1
      UniProtKB/Swiss-Prot
      P05063
      Related
      ENSMUSP00000099536.4, ENSMUST00000102478.4
      Conserved Domains (1) summary
      pfam00274
      Location:15363
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78213899..78218607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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