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    Nxnl2 nucleoredoxin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 75124, updated on 2-May-2024

    Summary

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    Official Symbol
    Nxnl2provided by MGI
    Official Full Name
    nucleoredoxin-like 2provided by MGI
    Primary source
    MGI:MGI:1922374
    See related
    Ensembl:ENSMUSG00000021396 AllianceGenome:MGI:1922374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdcvf2; 4930519N16Rik
    Summary
    Acts upstream of or within sensory perception of smell and visual perception. Orthologous to human NXNL2 (nucleoredoxin like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 4.3), testis adult (RPKM 1.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A5; 13 26.08 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (51324256..51329227)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (51168706..51175191)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32613 Neighboring gene STARR-seq mESC enhancer starr_34498 Neighboring gene STARR-seq mESC enhancer starr_34499 Neighboring gene STARR-seq mESC enhancer starr_34501 Neighboring gene STARR-seq mESC enhancer starr_34502 Neighboring gene STARR-seq mESC enhancer starr_34504 Neighboring gene RIKEN cDNA 9430083A17 gene Neighboring gene STARR-seq mESC enhancer starr_34507 Neighboring gene STARR-seq mESC enhancer starr_34508 Neighboring gene spindlin 1 Neighboring gene STARR-seq mESC enhancer starr_34509 Neighboring gene H2A histone family, pseudogene 2 Neighboring gene VISTA enhancer mm1300 Neighboring gene predicted gene, 29787 Neighboring gene STARR-seq mESC enhancer starr_34511 Neighboring gene STARR-positive B cell enhancer mm9_chr13:51370075-51370375

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage. Elachouri G, et al. Free Radic Biol Med, 2015 Apr. PMID 25596499
    2. Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity. Jaillard C, et al. Hum Mol Genet, 2012 May 15. PMID 22343139, Free PMC Article
    3. Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity. Lambard S, et al. PLoS One, 2010 Oct 7. PMID 20949100, Free PMC Article
    4. Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential. Chalmel F, et al. BMC Mol Biol, 2007 Aug 31. PMID 17764561, Free PMC Article
    5. Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Collin GB, et al. Cells, 2020 Apr 10. PMID 32290105, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study shows that Nxnl2 is a bi-functional gene involved in the maintenance of both the function and the viability of sensory neurons.
      Title: Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity.
    2. regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity
      Title: Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
    3. RdCVF2 shares many similarities with Rod-derived Cone Viability Factor in terms of gene structure, expression in a rod-dependent manner and protein 3D structure.
      Title: Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC27636

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in photoreceptor cell maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoredoxin-like protein 2
    Names
    rod-derived cone viability factor 2
    NP_001405689.1
    NP_083449.1
    XP_006517023.1
    XP_006517024.1
    XP_006517025.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418760.1 → NP_001405689.1  nucleoredoxin-like protein 2

      Status: VALIDATED

      Source sequence(s)
      AC160122
      UniProtKB/Swiss-Prot
      Q91WB0, Q9D531

    2. NM_029173.5 → NP_083449.1  nucleoredoxin-like protein 2

      See identical proteins and their annotated locations for NP_083449.1

      Status: VALIDATED

      Source sequence(s)
      AC160122
      Consensus CDS
      CCDS26511.1
      UniProtKB/Swiss-Prot
      Q91WB0, Q9D531
      Related
      ENSMUSP00000021828.5, ENSMUST00000021828.6
      Conserved Domains (1) summary
      cd02964
      Location:10 → 144
      TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      51324256..51329227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516962.5 → XP_006517025.1  nucleoredoxin-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006517025.1

      UniProtKB/Swiss-Prot
      Q91WB0, Q9D531
      Conserved Domains (1) summary
      cd02964
      Location:10 → 144
      TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...

    2. XM_006516961.5 → XP_006517024.1  nucleoredoxin-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006517024.1

      UniProtKB/Swiss-Prot
      Q91WB0, Q9D531
      Conserved Domains (1) summary
      cd02964
      Location:10 → 144
      TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...

    3. XM_006516960.2 → XP_006517023.1  nucleoredoxin-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006517023.1

      UniProtKB/Swiss-Prot
      Q91WB0, Q9D531
      Conserved Domains (1) summary
      cd02964
      Location:10 → 144
      TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D531.1 GenPept UniProtKB/Swiss-Prot:Q9D531

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