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    Zbtb8a zinc finger and BTB domain containing 8a [ Mus musculus (house mouse) ]

    Gene ID: 73680, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zbtb8aprovided by MGI
    Official Full Name
    zinc finger and BTB domain containing 8aprovided by MGI
    Primary source
    MGI:MGI:1920930
    See related
    Ensembl:ENSMUSG00000028807 AllianceGenome:MGI:1920930
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410081M15Rik
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZBTB8A (zinc finger and BTB domain containing 8A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.5), whole brain E14.5 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129247425..129271821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129353632..129378028, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene syncoilin Neighboring gene retinoblastoma binding protein 4, chromatin remodeling factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129012802-129012911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129013051-129013391 Neighboring gene zinc finger and BTB domain containing 8 opposite strand Neighboring gene STARR-seq mESC enhancer starr_11489 Neighboring gene STARR-seq mESC enhancer starr_11490 Neighboring gene RIKEN cDNA C330020E22 gene Neighboring gene STARR-seq mESC enhancer starr_11493 Neighboring gene STARR-seq mESC enhancer starr_11495 Neighboring gene zinc finger and BTB domain containing 8b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 8A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028603.4 → NP_082879.1  zinc finger and BTB domain-containing protein 8A

      See identical proteins and their annotated locations for NP_082879.1

      Status: PROVISIONAL

      Source sequence(s)
      AL607123
      Consensus CDS
      CCDS18690.1
      UniProtKB/Swiss-Prot
      Q8VD30, Q9CWH1
      Related
      ENSMUSP00000030610.3, ENSMUST00000030610.3
      Conserved Domains (5) summary
      smart00225
      Location:25 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:275 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:277 → 297
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14 → 119
      BTB; BTB/POZ domain
      pfam13465
      Location:289 → 314
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129247425..129271821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWH1.1 GenPept UniProtKB/Swiss-Prot:Q9CWH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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