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    Fbh1 F-box DNA helicase 1 [ Mus musculus (house mouse) ]

    Gene ID: 50755, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fbh1provided by MGI
    Official Full Name
    F-box DNA helicase 1provided by MGI
    Primary source
    MGI:MGI:1354699
    See related
    Ensembl:ENSMUSG00000058594 AllianceGenome:MGI:1354699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx18; Fbxo18
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination; replication fork processing; and replication fork protection. Acts upstream of or within negative regulation of chromatin binding activity and response to intra-S DNA damage checkpoint signaling. Predicted to be located in chromatin and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBH1 (F-box DNA helicase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.0), limb E14.5 (RPKM 13.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A1; 2 9.01 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11747384..11782396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11742573..11777585, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03677 Neighboring gene predicted gene, 39760 Neighboring gene predicted gene, 39759 Neighboring gene interleukin 15 receptor, alpha chain Neighboring gene predicted gene, 46731 Neighboring gene STARR-positive B cell enhancer ABC_E804 Neighboring gene ankyrin repeat domain 16 Neighboring gene STARR-seq mESC enhancer starr_03678 Neighboring gene STARR-seq mESC enhancer starr_03679 Neighboring gene predicted gene, 34768 Neighboring gene ankyrin repeat domain-containing protein 20A12 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress. Laulier C, et al. DNA Repair (Amst), 2010 Jun 4. PMID 20457012, Free PMC Article
    2. FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. Simandlova J, et al. J Biol Chem, 2013 Nov 22. PMID 24108124, Free PMC Article
    3. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Fugger K, et al. Nat Commun, 2013. PMID 23361013
    4. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. Wang Q, et al. BMC Genomics, 2011 Apr 21. PMID 21510876, Free PMC Article
    5. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
      Title: FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.
    2. FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.
      Title: FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
    3. role of the F-box helicase 1 (Fbh1) protein during genome maintenance in mammalian cells
      Title: Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box DNA helicase 1
    Names
    DNA 3'-5' helicase 1
    F-box only protein 18
    F-box protein 18
    NP_001335163.1
    NP_001335164.1
    NP_001335165.1
    NP_001335166.1
    NP_056607.1
    XP_006497568.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348234.1 → NP_001335163.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365 → 857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136 → 183
      F-box-like; F-box-like

    2. NM_001348235.1 → NP_001335164.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365 → 857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136 → 183
      F-box-like; F-box-like

    3. NM_001348236.1 → NP_001335165.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365 → 857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136 → 183
      F-box-like; F-box-like

    4. NM_001348237.1 → NP_001335166.1  F-box DNA helicase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK158937, AL831794, AL845548
      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (2) summary
      COG0210
      Location:365 → 857
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:136 → 183
      F-box-like; F-box-like

    5. NM_015792.2 → NP_056607.1  F-box DNA helicase 1 isoform 1

      See identical proteins and their annotated locations for NP_056607.1

      Status: VALIDATED

      Source sequence(s)
      AK003964, AK147829, AL831794, AL845548
      Consensus CDS
      CCDS15688.1
      UniProtKB/Swiss-Prot
      Q8C444, Q8K2I9, Q99KS0, Q9CTC6, Q9QZG7
      UniProtKB/TrEMBL
      Q3UGP2
      Related
      ENSMUSP00000071495.8, ENSMUST00000071564.14
      Conserved Domains (4) summary
      COG0210
      Location:439 → 931
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:210 → 259
      F-box-like; F-box-like
      pfam13538
      Location:870 → 931
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:440 → 684
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11747384..11782396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497505.3 → XP_006497568.1  F-box DNA helicase 1 isoform X1

      UniProtKB/TrEMBL
      Q3UGP2
      Conserved Domains (3) summary
      COG0210
      Location:439 → 931
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      cd18786
      Location:835 → 932
      SF1_C; C-terminal helicase domain of superfamily 1 DEAD/H-box helicases
      pfam12937
      Location:210 → 257
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2I9.1 GenPept UniProtKB/Swiss-Prot:Q8K2I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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